吡拉西坦联合尼莫地平治疗脑梗死后血管性痴呆的效果及对患者认知功能的影响探讨.pdfVIP

中国现代药物应用2023年4月第17卷第7期ChinJModDrugAppl,Apr2023,Vol.17,No.7·71·

吡拉西坦联合尼莫地平治疗脑梗死后血管性痴呆的

效果及对患者认知功能的影响探讨

钟彩琴吕俊杰

【摘要】目的探讨吡拉西坦联合尼莫地平治疗脑梗死后血管性痴呆的效果及对患者认知功能的

影响。方法82例脑梗死后血管性痴呆患者,根据随机数字表法分为观察组和对照组,各41例。对照

组采用尼莫地平治疗,观察组采用吡拉西坦联合尼莫地平治疗。比较两组治疗效果及精神状态、健康状

况评分。结果观察组治疗总有效率92.7%高于对照组的75.6%,差异有统计学意义(P0.05)。治疗后,

观察组简易精神状态检查量表(MMSE)评分(26.8±3.7)分、健康调查简表(SF-36)评分(58.3±6.7)分均

高于对照组的(22.1±4.1)、(51.3±6.2)分,差异有统计学意义(P0.05)。结论吡拉西坦联合尼莫地平

治疗脑梗死后血管性痴呆的效果显著,可有效改善患者的认知功能,值得借鉴。

【关键词】脑梗死；血管性痴呆；尼莫地平；吡拉西坦；认知功能；健康状况

DOI：10.14164/j.cnki.cn11-5581/r.2023.07.020

Effectofpiracetamcombinedwithnimodipineonpatientswithvasculardementiaaftercerebral

infarctionanditsinfluenceoncognitivefunctionZHONGCai-qin,LYUJun-jie.DepartmentofNeurology,

JinzhouCentralHospital,Jinzhou121000,China

【Abstract】ObjectiveTodiscusstheroleofpiracetamcombinedwithnimodipineonpatientswith

vasculardementiaaftercerebralinfarctionanditsinfluenceoncognitivefunction.MethodsAtotalof82patients

withvasculardementiaaftercerebralinfarctionweredividedintoobservationgroupandcontrolgroupaccording

totherandomnumericaltable,with41casesineachgroup.Thecontrolgroupwastreatedwithnimodipine,and

theobservationgroupwastreatedwithpiracetamandnimodipine.Thetherapeuticeffect,mentalstateandhealth

statusscoreswerecomparedbetweenthetwogroups.ResultsThetotaleffectiverateoftheobservationgroupwas

92.7%,whichwashigherthanthatof75.6%ofthecontrolgroup,andthedifferencewasstatisticallysignificant

(P0.05).Aftertreatment,thescoresofMMSEof(26.8±3.7)pointsandscoreofSF-36of(58.3±6.7)points

intheobservationgroupwerehigherthanthoseof(22.1±4.1)and(51.3±6.2)pointsinthecontrolgroup,and

thedifferenceswerestatisticallysignificant(P0.05).ConclusionPiraceta