2型糖尿病患者谷氨酸脱羧酶抗体水平与认知功能障碍的相关性研究.docx

?

?

2型糖尿病患者谷氨酸脱羧酶抗体水平与认知功能障碍的相关性研究

?

?

杨本德王恒柳蕾

[摘要]目的探讨2型糖尿病患者谷氨酸脱羧酶抗体（GAD-Ab）水平与认知功能障碍之间的相关性。方法根据简易智力状态检查（MMSE）评分将2015年1月～2016年12月我院收治的80例2型糖尿病患者分为认知障碍组（A组，n=40）与非认知障碍组（B组，n=40），另选取40例健康体检者为对照组（C组）。采用酶联免疫吸附法检测各组外周血血清中GAD-Ab的水平。结果A组的GAD-Ab水平高于B、C组，差异有统计学意义（P0.05）;A组患者的MMSE评分与血清GAD-Ab水平成负相关（r=-0.966，P=0.00）。结论GAD-Ab的水平可作为2型糖尿病患者认知功能障碍预测、早期诊断、早期治疗的标志之一，对减少认知功能障碍的患病概率有指导意义。

[关键词]2型糖尿病;谷氨酸脱羧酶抗体;认知功能障碍

[]R747.9?????[]A?????[]1674-4721（2019）12（c）-0120-03

Correlationalresearchbetweenglutamicaciddecarboxylaseantibodylevelandcognitivedysfunctioninpatientswithtype2diabeticmellitus

YANGBen-de?WANGHeng?LIULei?GUOXiu-feng

DepartmentofRehabilitation，LaigangHospitalAffiliatedtoShandongFirstMedicalUniversity，ShandongProvince，Jinan?271126，China

[Abstract]ObjectiveToinvestigatethecorrelationbetweenglutamicaciddecarboxylaseantibody（GAD-Ab）levelandcognitivedysfunctioninpatientswithtype2diabetesmellitus.MethodsAtotalof80patientswithtype2diabetesmellitusadmittedtoourhospitalfromJanuary2015toDecember2016weredividedintocognitiveimpairmentgroup（groupA，n=40）andnon-cognitiveimpairmentgroup（groupB，n=40）andanother40healthysubjectsascontrolgroup（groupC）accordingtoMMSEscore.ThelevelsofGAD-Abinperipheralbloodserumofeachgroupweredetectedbyenzyme-linkedimmunosorbentassay.ResultsTheGAD-AblevelingroupAwashigherthanthatingroupBandgroupC，withsignificantdifferences（P0.05）.MMSEscoresofpatientsingroupAwerenegativelycorrelatedwithserumGAD-Ablevels（r=-0.966，P=0.00）.ConclusionThelevelofGAD-Abcanbeusedasoneofthemarkersofcognitivedysfunctionprediction，earlydiagnosisandearlytreatmentinpatientswithtype2diabetesmellitus，andhasguidingsignificanceforreducingtheincidencerateofcognitivedysfunction.

[Keywords]Type2diabetesmellitus;Glutamicaciddecarboxylaseantibody;CognitiveDysfu