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第32页,共38页,星期六,2024年,5月第33页,共38页,星期六,2024年,5月第34页,共38页,星期六,2024年,5月History,physicalexamination,respiratoryfunctiontestFEV1orPEF50%▲?2-agonistupto3timesin1sth▲O2toachieveO2saturation≥90%▲pocorticosteroidsFEV1orPEF50%(severeexacerbation)▲InhaledH-dose?2agonistandM-Rblockerevery20minorcontinuouslyfor1h▲OxygentoachieveO2saturation≥90%▲pocorticosteroidsImpendingoracuterespiratoryarrest▲artificialventilationwith100%O2▲Inhaled?2agonistandM-Rblocker▲IvcorticosteroidsRepeatasssessmentModerateexacerbation(FEV1orPEF50%-80%)▲Inhaledshort-acting?2agonistevery60min▲Systemiccorticosteroids▲Continuetreatment1-3h,ifthereisimprovementSevereexacerbation(FEV1orPEF50%)▲Inhaledshort-acting?2agonist,hourly,orcontinuously+InhaledM-Rblocker▲Oxygen▲SystemiccorticosteroidsIntensivecareGoodresponse▲FEV1orPEF≥70%▲Keepresposefor60minaftertreatment▲Nodisdress▲Physicalexam:normalDischargehome▲Continuetreatinginhaled?2agonist▲Continuecourseoforalcorticosteroid▲Patienteducation-reviewmedicineuseReviewinitialactionplan-RecommendclosemedicalfollowupPoorresponse▲FEV1orPEF50%▲PCO2≥42MGHg▲Physicalexam:systemssevere,drowsiness.confusionAdmittohospitalintensivecare▲Inhaled?2agonisthourlyorcontinuouslyinhaledM-Rblocker▲Ivcorticosteroid▲Oxygen▲PossibleintubationandmechanicalventilationIncompleteresponse(FEV1orPEF≥50%but70%Adimittohospitalward▲Inhaled?2agonist+inhaledM-Rblocker▲Systemic(poorIV)corticosteroid▲Oxygen▲MonitorFEV1orPEFImproveanddischargehome▲Continuetreatinginhaled?2agonost▲Continuecourseoforalcorticosteroid▲Patienteducation-Reviewmedicineuse-Review/initiateactionplan-Recommendclosemedicalfollow-upFig2Emergencydepartmentandhospitalcareofacuteasthmaexacerbations第35页,共38页,星期六,2024年,5月Tab5Relativeselectivity,potency,and
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