定位方法对直线加速器发射治疗晚期食管癌的临床疗效-国际临床研究杂志.docx

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定位方法对直线加速器发射治疗晚期食管癌的临床疗效

【摘要】目的分析晚期食管癌开展直线加速器放射治疗时，实施不同定位方法所体现的疗效差别。方法研究纳入我院确诊并开展直线加速器发射治疗的晚期食管癌患者，时段2022年12月-2023年12月。将全体50例依照随机数字表法划分成两组，每组平均25例。两组均采用直线加速器放射治疗，对照组应用常规钡餐定位，观察组应用CT模拟定位，对比两组治疗效果。结果观察组在采用CT模拟定位下直线加速器放射治疗后，其客观缓解率、肿瘤标志物水平均优于对照组，组间差异显著（P＜0.05）。两组不良事件发生率差异无统计学意义（P0.05）。结论晚期食管癌开展直线加速器放射治疗时，采取CT模拟定位可使临床疗效进一步提升，改善肿瘤标志物，具备良好安全保障。

【关键词】钡餐定位；CT模拟定位；直线加速器；晚期食管癌

【收稿日期】2024年1月17日【出刊日期】2024年2月23日【DOI】10.12208/j.ijcrClinicalefficacyofpositioningmethodsinthetreatmentofadvancedesophagealcancerwithlinearacceleratoremissiontherapy

JieCui,HongchengLi

XinruiHospitalinXinwuDistrict,Wuxi,Jiangsu

【Abstract】ObjectiveToanalyzethetherapeuticeffectofdifferentlocalizationmethodsinlinearacceleratorradiotherapyforadvancedesophagealcancer.MethodsPatientswithadvancedesophagealcancerdiagnosedinourhospitalandtreatedwithlinearacceleratoremissionwerestudiedfromDecember2022.DecembertoDecember2023.December.

All50casesweredividedintotwogroupsaccordingtorandomnumbertablemethod,withanaverageof25casesineachgroup.Thetwogroupsweretreatedwithlinearacceleratorradiotherapy,thecontrolgroupwastreatedwithconventionalbariummealpositioning,theobservationgroupwastreatedwithCTsimulatedpositioning,andthetherapeuticeffectofthetwogroupswascompared.ResultsTheobjectiveresponserateandtumormarkerleveloftheobservationgroupwerebetterthanthoseofthecontrolgroupafterlinearacceleratorradiotherapywithsimulatedCTpositioning,andthedifferencesbetweenthegroupsweresignificant(P0.05).Therewasnosignificantdifferenceintheincidenceofadverseeventsbetweenthetwogroups(P0.05).ConclusionInthetreatmentofadvancedesophagealcancerwithlinearacceleratorradiotherapy,CTsimulatedlocalizationcanfurtherimproveclinicalefficacy,improvetumormarkers,andhavegood