朝阳市某专科学校新生乙肝疫苗接种情况调查分析.pdfVIP

朝阳市某专科学校新生乙肝疫苗接种情况调查分析

【摘要】目的了解辽宁省朝阳市师范高等专科学校3年制大专2008届

1475名新入校学生乙肝疫苗的接种情况,为有针对性的制定乙肝预防控制策略提

供依据。方法选择2008届3年制大专新入校的1475名学生作为研究对象,进

行乙肝疫苗接种情况问卷调查和乙肝两对半检查;对HBV5项指标(HBsAg、抗

-HBs、HBeAg、抗-HBe、抗HBc)检查均为阴性、肝功能检查为正常的新生按照

“0、1、6”方案,进行乙肝疫苗接种。对1个月后检测抗-HBs为阴性的学生,实施

增加剂量(10μg/ml)按照“0、1、2”方案进行接种,并对接种效果进行统计分析。结

果1475名新入校学生的乙肝疫苗接种率为74.03%,HBsAg阳性率为5.67%。420

名新生疫苗初次接种1个月后,抗-HBs阳转率为76.43%,男生与女生阳转率差别

不显著(P＞0.05)。对检验抗-HBs为阴性的99名新生,采取增加剂量第2次复,阳

转率为100%。在问卷调查中,部分新生对乙肝的危害认识不够,缺乏自觉接种的意

识。结论乙肝疫苗接种是防止HBV感染的有效方法,疫苗复种是目前有效,切实

可行的解决乙肝疫苗无应答问题的手段。

【Abstract】ObjectiveTheaimofthisstudywastoinvestigatetherateof

hepatitisBvaccineamongthefreshmenofthree-yearsandtheimmunityeffectafter

vaccination,andtoprovidereferenceforfurtherpreventionandcontrol.Methods1475

freshmenofthree-yearswerecollected,andinvestigatedabouthepatitisBvaccinated,

anddetectedthethemarker(HBsAg,anti-HBS,HBeAganti-HBeandAnti-HBc)of

hepatitisB;thefivetargetsofHBVwereshowedtobenegative,andnormalliver

functionwereimmunizedwithhepatitisBvaccinebyusing0,1,and6months

schemes,iffreshmenwiththenegativeanti-HBsatthetimeofonemonthwere

immunizedwithhepatitisBvaccineinlargedosesbyusing0,1,and2-months

schemes.ResultsAmong1475freshmen,therateofhepatitisBvaccinatedwas

74.03%.Aftertheprimaryvaccinatedforonemonth,theconversionrateofanti-HBs

positivewas76.43%,andnosignificantdifferencewasfoundbetweentheconversion

ratesofmalesandfemales(χ2=1.19P＞0.05).Forfreshmenwithnegativeanti-HBs,we

usedthesecondfull-courseimmunizationwithlargedose,andtheconversionrateof

positiveanti-HBswas100%.ConclusionThehepatitisBvaccinationisthebest

effectivewayofpreventingHBVinfection,andtherevaccinationofvaccineis

effective