chapter 10 analysing and presenting results10章分析呈现结果.pdfVIP

Contents

10.1

Introduction4

10.1.1

Aimsofmeta-analysisforDTAreviews4

10.1.2

Whennottouseameta-analysisinareview5

10.1.3

Howdoesmeta-analysisofdiagnostictestaccuracydifferfrommeta-analysisofinterventions?5

10.1.4

QuestionswhichcanbeaddressedinDTAanalyses6

Whatistheaccuracyofatest?6

Howdoestheaccuracyvarywithclinicalandmethodologicalcharacteristics?6

Howdoestheaccuracyoftwoormoretestscompare?6

10.1.5

Planningtheanalysis7

10.1.6

Writingtheanalysissectionoftheprotocol7

10.2

Keyconcepts8

10.2.1

Diseasestatus8

10.2.2

Typesoftestdata9

10.2.3

Analysisofaprimarytestaccuracystudy9

SensitivityandSpecificity10

Predictivevalues10

Likelihoodratios10

Diagnosticoddsratios11

10.2.4

Positivitythresholds11

10.2.5

ROCcurves13

10.2.6

RelationshipsbetweenROCcurves,diagnosticoddsratiosandQ*14

10.3

Graphicalandtabularpresentation15

10.3.1

SummaryROCplots15

10.3.2

LinkedROCplots16

10.3.3

Coupledforestplots16

10.3.4

Example1:Anti-forthediagnosisofrheumatoidarthritis-DescriptivePlots.16

10.3.5

Tablesofresults18

10.4

Meta-analyticalsummaries18

10.4.1

ShouldIestimateaSRO