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医学课件：肝细胞癌(英文版)汇报人：文小库xx年xx月xx日
CATALOGUE目录INTRODUCTIONETIOLOGYANDRISKFACTORSCLINICALMANIFESTATIONSANDDIAGNOSISTREATMENTANDMANAGEMENT
CATALOGUE目录PROGNOSTICATIONANDSURVIVALPREVENTIONANDCOURSEMODIFICATION
01INTRODUCTION
DefinitionofHepatocellularCarcinoma(HCC)Hepatocellularcarcinoma(HCC)isaprimarymalignancyoftheliver,accountingforapproximately90%ofallprimarylivercancers.Itisahighlyheterogeneousdiseasewithmultipleetiologies,includinghepatitisBvirus(HBV),hepatitisCvirus(HCV),alcohol,andotherfactors.
Thefive-yearsurvivalrateofHCCispoor,generallylessthan10%.HCCisthethirdleadingcauseofcancer-relateddeathworldwide.GlobalBurdenandImportanceofHCCTheincidenceofHCCisincreasing,withover700,000newcasesdiagnosedannually.
HCCcanbeclassifiedintodifferentsubtypesbasedonhistologicandmolecularcharacteristics,whichcanhelppredictprognosisandresponsetotherapy.HCCClassificationandStagingTheBCLCstagingsystemcanhelpguidetreatmentoptionsandpredictpatientoutcomes.
02ETIOLOGYANDRISKFACTORS
HepatitisBvirus(HBV):ThemostcommoncauseofHCCworldwideAlcohol:Asignificantfactorin肝细胞癌developmentNon-alcoholicsteatohepatitis(NASH):AnemergingcauseofHCCHepatitisCvirus(HCV):ThesecondmostcommoncauseofHCCEtiologyofHCC
CirrhosisAnycauseofcirrhosiscanleadtothedevelopmentofHCCAgeHCCisuncommoninpeopleunder40yearsoldbuttheriskincreaseswithageGenderMalesareslightlymorelikelytodevelopHCCthanfemalesEthnicitySomeethnicgroupsareathigherriskofdevelopingHCCRiskFactorsforHCCDevelopmenVSAgeneticdisorderthatcausesironoverloadandliverdamageAlpha-1An…AgeneticdisorderthatcausesliverdamageandHCCinsomepatientsHereditary…GeneticRiskFactorsforHCC
03CLINICALMANIFESTATIONSANDDIAGNOSIS
SymptomsandSignsofHCC要点三AbdominalpainHCCtumorscancompressorinvadenearbytissues,causingp
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