CTX-M-changing the face of ESBLs in the UK国外耐药菌检测.pdf

CTX-M-changing the face of ESBLs in the UK国外耐药菌检测.pdf

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JournalofAntimicrobialChemotherapy(2005)56,451–454

doi:10.1093/jac/dki239

AdvanceAccesspublication8July2005

CTX-M:changingthefaceofESBLsintheUK

D.M.Livermore1andP.M.Hawkey2,3*

1AntibioticResistanceMonitoringandReferenceLaboratory,CentreforInfections,HealthProtectionAgency,

61ColindaleAvenue,LondonNW95HT,UK;2DivisionofImmunityandInfection,UniversityofBirmingham,

BirminghamB152TT,UK;3HealthProtectionAgencyWestMidlandsPublicHealthLaboratory,

BirminghamHeartlandsandSolihullNHSTrust,BordesleyGreenEast,BirminghamB95SS,UK

TheUKhasexperiencedasuddenriseinextended-spectrumb-lactamase(ESBL)rates,largelyduetothe

appearanceandspreadofEscherichiacoliproducingCTX-M-15typeb-lactamase.TheBritishSocietyfor

AntimicrobialChemotherapyorganizedtwoupdatemeetingsduring2004toreportanddiscusstherecog-

nition,clinicaldiagnosis,treatmentandcontrolofbacteriaproducingtheseb-lactamases.Thispaper

reportsthedataandreviewsmadebycontributorstotheconferences.Thehistoricaldistributionand

emergenceofESBLswasreviewedalongwiththeemergenceofplasmid-mediatedCTX-MESBLsfollowing

theirmobilizationfromthechromosomeofKluyveraspp.ThefirstsignificantoutbreakofCTX-Mproducers

intheUKoccurredin2001andinvolvedKlebsiellapneumoniaewithCTX-M-26atonesite,butby2003,

clonedanddiverseE.coliwithCTX-M-15werewidespread,withShropshireoneofthemostaffected

regions.ThespecificexperienceinShropshirewasreportedonandacomprehensivereviewmadeof

thelevelofawarenessoftheneedforESBLdetectioninlaboratoriesinEnglandandWales,together

with

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