关节炎英文专题知识.pptx

PathologyofArthritis

Dr.VenkateshM.Shashidhar.

AssociateProfessorofPathology

FijiSchoolofMedicine

Mobility-Cranialsutures→Shoulderjoint.

Articularcartilage-hyaline-frictionres.

Synovialfluid-lubric/nutri,TypeAB

synoviocytes.Hyaluronidase

Continuousproductionandabsorption.AffectedbyInflammation,immobility.

Capsule,ligaments,menisci.

Vascular,richnervesupply

-Art.Cartilage*

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Arthritis

Joints-Anatomy

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Inflammationofjoints-Common

Commonsiteforautoimmuneinjury

·HeartvalvesJoints-damage-Exposureofhiddenantigens.

Infections.

Degeneration-Age/Stress/lifestyle

UseitorLooseit..!

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Arthritis-Introduction

Arthritis

Pain

→Inflammation-capsule,synovium,periosteum.

Swelling:

·→inflammation,effusion,proliferation.

Restrictedmovement

·→pain,fluid,synovialswelling,damage.

Deformity

→mal-alignment,erosion,ankylosis

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Arthritis-Clinicalfeatures:

Arthritis

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ArthritisClinicalClassification:

Monoarthritis:

·Local,asymmetric,secondary.

·Acute:Bacterial,Trauma,Crystal,Reactive

·Chronic:Tuberculosis,Lyme,Fungal,Trauma,Tumors.

Polyarthritis:

Chronic,symmetric,systemic.

·Autoimmune,degenerative,Crystal.

·Rarelyinfective.

Autoimmune:

·Rheumatic,Rheumatoid,Ankylosingspondylitis,Reitersyndromeetc.

Degenerative:Osteroarthritis

CrystalDeposition:

■Gout-Monosodiumurate

■CPPD-PseudoGout

Infective-Septic,TB,Lymeetc.rare.

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PolyarthritisClassification:

Arthritis

RheumatoidArthritis

Prevalenceabout1%ofUSpopulation

Female:Maleratio=2:1

StrongassociationwithHLADR4.

Concordanceinidenticaltwinsonly30%

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