【word】无脉络膜症一家系.doc

【word】无脉络膜症一家系

无脉络膜症一家系

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是因为缺氧导致过度表达的VEGF在很大程度上被转

移的sFlt.1竞争性结合,以致VEGF诱导KDR/Flk-1

表达上调的正反馈机制受到抑制,KDR/Flk.1的表达

不能同模型对照组一样放大.

本实验表明慢病毒介导的sFh.基因片段的转移

能有效抑制小鼠视网膜新生血管的发生,初步肯定了

sFlt.1在视网膜新生血管疾病方面的研究价值.虽然

sFh.1的研究尚处于实验研究阶段,但其具有的研究

价值和应用前景可为人视网膜新生血管疾病的防治提

供了一个新的方向.

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