药物特异质肝损伤因素、机制及损伤病机探析.pdfVIP

药物特异质肝损伤因素、机制及损伤病机探析

药物特异质肝损伤是指发生在少数易感人群中间的一种与药物药理作用及

临床剂量无关且所占比例较高的特异质性药物不良反应。其中由中药所导致的特

异质性肝损伤的比例有逐年增加的趨势。该文综述了近年来药物特异质肝损伤风

险因素及发生机制，分析中药引起的特异质肝损伤特点及研究现状，探究中医体

质与特异质肝损伤的内在联系，以期为中药特异质肝损伤预防、诊断和治疗提供

借鉴。

标签：特异质肝损伤；不良反应；影响因素；发生机制

Discussiononinfluencefactors，mechanismandtraditionalChinese

medicinepathogenesisofidiosyncraticdruginducedliverinjury

WANGGang1，2，LIUYing1，2，HOUXuefeng1，2，SONGJie2，QIU

Huihui2，ZHONGQingxiang2，

JIAXiaobin2*，WANGFujing1，2，JIANGNan1，2，KEZhongcheng2，

FENGLiang2*

（1SchoolofPharmacy，AnhuiUniversityofChineseMedicine，Hefei

230012，China；

2KeyLaboratoryofNewDrugDeliverySystemofChineseMateriaMedica，

JiangsuProvincialAcademyof

ChineseMedicine，Nanjing210028，China）

[Abstract]Idiosyncraticdruginducedliverinjury（IDILI）isakindofunique

adversedrugreactionwithrelativehighmorbiditycomparedwithotheridiosyncratic

diseasesItsoccurrence，however，hasnothingtodowithpharmacologicaleffects

andclinicaldosageofdrugsadministered，andonlyasmallnumberofsusceptible

individualswillsufferfromitEspeciallytodeservetobementioned，theproportion

ofTCMinducedIDILIshowedanascendingtrendyearbyyearSointhisarticle，the

authorhasreviewedsomefactsrelatedwithTCMinducedIDILI，includingthe

predisposingcausesandoccurrencemechanism，andtriestoprovidereferencefor

theprevention，diagnosisandtreatmentofTCMinducedIDILIthroughtheanalysis

ofcharacteristicsandresearchstatusofTCMinducedIDILIandexplorationofthe

internalrelationshipbetweenChinesemedicineconstitutiontypeandIDILI

[Keywords]idiosyncraticdruginducedliverinjury；adversedrugreaction；

influencefactors；occurrencemechanism

随着药物性肝损伤临床病例报道的日益增多，以及药源性肝损伤导致上市药

物撤出市场或被标注“黑框”警示[1]，药物性肝损伤已引起广泛的关注。基于发生

机制的不同，药物性肝损伤通常分为固