SurePathTM液体基质细胞学与常规涂片细胞学在食管、胃和十二指肠病变的内镜超声引导采样中的比较.pdf

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Medicine

ClinicalTrial/ExperimentalStudy

Aprospectiverandomizednoninferioritytrial

comparingconventionalsmearsandSurePathTM

liquid-basedcytologyinendoscopicultrasound-

guidedsamplingofesophageal,gastric,and

duodenallesions

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JaeChang

Jun,MD,SangHyub

Lee,MD,PhD,HanMyung

Lee,MD,SangGyun

Kim,MD,PhD,

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Hyunsoo

Chung,MD,PhD,JooSeong

Kim,MD,PhD,Namyoung

Park,MD,JinHo

Choi,MD,PhD,

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Yoonjin

Kwak,MD,PhD,Soo-Jeong

Cho,MD,PhD*

Abstract

Background:Severalliquid-basedcytology(LBC)methodsarecurrentlyused,butthediagnosticaccuracyofeachmethodis

notwellknown.WeaimedtocomparethediagnosticperformanceofSurePathTMLBCandconventionalsmear(CS)cytologyin

endoscopicultrasound-guidedfineneedleaspiration(EUS-FNA)samplesofesophageal,gastric,andduodenallesions.

Methods:Asaprospectiverandomizednoninferioritystudy,patientswhoneededEUS-FNAduetosubepithelialmassinthe

uppergastrointestinaltractwererandomlyassigned1:1totheLBCandCSgroups.Cytologicpreparationwascarriedoutusing

acrossoverdesignwhere1methodwasusedforthefirstneedle-passsampleandanothermethodwasusedforthesecond

needle-passsample.TheprimaryoutcomewastocomparethediagnosticperformancebetweenLBCandCSusingthefinal

diagnosis