生物信息学ppt课件：1-大数据时代的组学研究.pptxVIP

大数据时代的生命组学研究 王理中 Metabolomics Behavioromics Genomics amICS oms Morphomics⁶ Toxicogenomics Phosphoproteomics Archaeomics Epigenomics Iranscriptomics Regulomics Proteomics TraditionalVSModernways 阳 警 COMPLEX RXR BRCA actin ras SESR MVG 心 以 3 S DSK SDCAL M Wnt SIE 2 · 1st: Sanger · 2nd:Illumina Solexa; Roche 454; ABISOLID · 3rd:PacBio SMRT; Oxford Nanopore Primer, dNTPs template. and polymerase 100-200 ilion beads Chemically linked to a Bre akthrough of sequencing technologies b llumina/Solen Smole preparatign 认 5 Template dNTh Solid-phase amplfication One DNA moiecule per cinter Thousands of primed single molecle templates cross glass slide Top. CλTcoT Human Genome Project(HGP) nature the genome 1990 The Human Genome Project (HGP) launched in the United States Twenty-five years of big biology COMMENT consoctium-based science it wheredin,ay ErleD.Green,James D.Watson and FrancisS.Collins. human 2015 2003 1984 1990 4 The nations of the world must see that the human genome belongs to the worlds people, as opposed to its nations. -- James D. Watson 5 The 1000 Genomes Project The 1000 Genomes Project A global reference for human genetic variation The 1000 Genomes Project Consortium* )oooiwemormg rmp normdus All organisms have a genome After Human genome . 2002 2007 2000 Plant: had bee sequenced 2008 2012 Anopheles Anoptuvs gambae Caenorhabditis slegans Fruitly Doasophia malanogasis Eiephant Loxodonta athicana Hyrax Frocavia capenais Lesser hedgehog tenrec Echinoos ielfam Ciona intestinalis Cigna savigny Anole Litard Anait caoinns Chicken Gala galus Zebra Finch Taenopiga gwtla Opossum Mnodethis domestics Platypus mhomjnchus Dssjps novemcinctos Sloth Chokopus hoframm Lamprey Plants Animals Xenopus tropicalis Bushbaby Oiolemur ganati Chimpanzee Pan trogioditss Gonilla Gorla gorla Macague Macaca mulste Mouse Lemur Mcroosbus munnus Orangutan Fongo pigmaeut Tarsier Tarsua syic