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Hemorrhogic Fever
Prepared by
Dept. of microbiology and parasitology
Hemorrhogic Fever
Hantaar or HEMORRHAGIC FEVER
with renal syndrome ( HFRS )
Xing Jiang Hemorrhogic Fever
Hantaar
(HEMORRHAGIC FEVER with renal
syndrome,肾综合症 热)
(Hantaar pulmonary syndrome,汉坦
肺综合症)
Morphology
Spherical, 80-210nm
Nucleocapsid: Helical, 3 segments, 2
proteins - nucleocapsid (N), RNA
polymerase (L)
Envelope: 2 glycoproteins, G1 and G2,
Morphology
RNA POLYMERSE
Biological properties
1. ssRNA with long, medium,short segments
2. 6 serotypes (I- VI)
3. : weak
Epidemiology
1. Natural host : rodents (deer mouse
(Peromyscus maniculatus), cotton rat
(Sigmodon hispidus), marsh rice rat (Oryzomys
palustris ) , white-footed mouse (Peromyscus
leucopus), other carriers)
2. Transmission : Droplet (飞沫) and rodent
excreta spread
3. Season and district
Clinical syndromes
Headache;
Pink in face , neck
Fever
marked bleeding tendency
Lower blood pressure
Urine with Protein
multi-organ failure
Pathogenicity
1. Clinical manifestations: 5 phases
Fever phase
Hypotension低血压 phase
Auria phase
Polyuria phase
convalescent phase
Pathogenesis
Viral direct damage
Immunopathogenesis
Laboratory diagnosis
Cultivation: Vero-E6 cell and A549 cell
Serological diagnosis: IgM/IgG
indirect immunofluorescent assay
ELISA-IgM
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