obligateanaerobes-近畿大学医学部.ppt

109-A13重症熱性血小板減少症候群SFTS: severe fever with thrombocytopenia syndromeSFTSウイルス：Bunyaviridae科Phlebovirus属マダニ媒介四類感染症 March to July 2021, Emerging infectious disease identified as the severe fever with thrombocytopenia syndrome (SFTS) in rural central China. Cause was unknown. Major clinical symptoms included fever, thrombocytopenia, gastrointestinal symptoms, and leukocytopenia; high initial case fatality rate of 30%Multi-organ failure developed RAPIDLY—elevated serum alanine aminotransferase, aspartate aminotransferase, creatine kinase, lactate dehyrogenase; proteinuria, hematuria.From Dr. O’Callaghan Virology Journal Club April 29, 2021 Genus Human diseaseOrthobunyavirus La Crosse encephalitis, California encephalitis Phlebovirus Rift Valley fever (RVF)Nairovirus Crimean-Congo hemorrhagic fever (CCHF)Hantavirus Hemorrhagic fever with renal syndrome (HFRS) Hantavirus pulmonary syndrome (HPS)Tospovirus Plant virus, no known human disease5 generaFamily BunyaviridaeEncephalitisHemorrhagic FeverPneumonia BUNYAVIRIDAE; Bunyamwera in Uganda Virion: ENV, 120nm; 3 Helical capsids; three 1X RNAs5 Genera. 2 genera have ambisense RNAs; Phelbovirus TospovirusTospovirus genus = tomato spotted wilt virus M S RNAs are ambisense. NSm 34K protein = movement. Forms tubules that penetrate thru plasmadesmata so capsids can enter neighboring cell. NSs 52K protein binds 2X RNA that can generate siRNAs . Transmitted by THIRPSInfects tomato, peanuts, watermelon, zucchini, impatiensS+M RNAs = ambiCalifornia Sin NombreCCHFRift ValleyDr. O’Callaghan Journal Club 4/20/12 Hantavirus (HFRS contact with rodents) Nairovirus (CCHF-tick) Orthobunyavirus (LAC mosquito) Phlebovirus (Rift Valley Fever; mosquito) Tospovirus (Tomato spotted wilt ; thrips)PHLEBOVIRUS: 68 serotypes. Two Groups: