流行病学英文讨论课题目.ppt

流行病学英文讨论课题目 Part 1 clinical trial1.1 Researchers conduct a randomized controlled trial to determine if Med A reduces post-operative pain more than Med B. The primary purpose of double blinding this trial is to avoid: A. recall bias B. selection bias C. confounding bias D. non-random (differential) misclassification of exposure status E. non-random (differential) misclassification of outcome status 1.2 The main benefit of a randomized controlled trial (RCT) compared to all other epidemiologic study design is that the RCT: is prospective thereby eliminating the need for historical data has better external validity guarantees that confounding bias will not occur tends to equally distribute into the study arms characteristics which may be independent risk factors for the outcome of interest tends to avoid random misclassification of the outcome of interest 1.3 is a method that maximizes the probability that the two groups will be similar in background characteristics that may influence either the response to therapy or the primary outcome measure.blindingRandomizationdiagnostic criteriaplacebo-controlled trial. ? 1.4 Fill the blank with ”yes ”or “no”Knowledge of Treatment AssignmentBlindingPatient?InvestigatorNoneSingleDouble Results of the coronary artery disease (CAD) Therapy Trial Concerning the Risk of Developing MI?Treatment? myocardial infarction Medicine AMedicine B TotalYes9123114No287325612Total378348726 1.5 Calculate the risk of developing MI in each treatment group.1.6 What is the percentage of risk of MI that would be avoided if Medicine B were used instead of Medicine A?1.7 What is relative risk or rate ratio? How to explain its epidemiological significance? Part 2 Cohort study Case Control study 2.1 when the incidence rate of the disease is rare, what kind of study is most suitable to explore the underlying etiology? A Prospective studyB case- controlC descriptive studyD clinical trial 2.2 For each of the following features,