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Neuroradiology (2015) 57:599 604
10.1007/s00234 015 1501 0
INTERVENTIONAL NEURORADIOLOGY
GREAT—a randomized aneurysm trial. Design of a randomized
controlled multicenter study comparing HydroSoft/HydroFrame
and bare tinum coils for endovascular aneurysm treatment
Christian Taschner RenéChapot V ent Costalat Patrick Courthéoux
Xavier Barreau Jerome Berge Laurent Pierot Kryzsztof Kadziolka
Betty n Raphael Blanc Alessandra Biondi HervéBrunel Sophie Gallas
Ansgar Berlis Denis Herbreteau Joachim Berkefeld Christoph Groden
Horst Urbach Samer El Shikh Erika Graf Alain Bonafé
Received: 4 December 2014 / Accepted: 13 February 2015 / Published online: 28 February 2015
# Verlag Berlin Heidelberg 2015
The effectiveness of a hybrid hydrogel tinum the HydroCoil, have been developed and brought to clinical
detachable coil (HydroCoil; MicroVention ., Tustin, CA) practice. The present study aims to compare the effectiveness
for endovascular aneurysm treatment has been proven in a of endovascular aneurysm treatment with coil embolization
recently published RCT. Due to technical restrictions (coil between patients allocated HydroSoft/HydroFrame versus
stiffness, time restriction for cement), the HydroSoft coil bare tinum coiling. GREAT is a randomized, controlled,
as well as a corresponding 3D framing coil, the HydroFrame multicentre trial in patients bearing cerebral aneurysms to be
coil (MicroVention ., Tustin, CA), a class of new softer treated by coil embolization. Eligible patients were random-
coils containing less hydrogel and swelling more slowly than ized to either coil embolization with HydroSoft/HydroFrame
C. Taschner (*) :H. Urbach :S. El Shikh
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