软骨肉瘤的学习资料.pptxVIP

软骨肉瘤的学习资料第1页/共16页 DiaphysisMyeloid多发性骨髓瘤（Multiple myeloma）Epithelial釉质细胞瘤（Adamantinoma）PNETEwing’s sarcomaMetaphysisOsteoblast骨样骨瘤 成骨细胞瘤（Osteoblastoma） 骨瘤（Osteoma） 骨肉瘤（Osteosarcoma） Chondroblast软骨瘤 软骨肉瘤（Chondrosarcoma） 骨软骨瘤 软骨粘液样纤维瘤Fibrous骨化纤维瘤（Ossifying fibroma） 纤维肉瘤（Fibrosarcoma）EpiphysisChondroblast成软骨细胞瘤（Chondroblastoma）Myeloid骨巨细胞瘤（Giant cell tumor of bone）OtherNotochord脊索瘤(Chordoma)第2页/共16页 SITE OF LONG BONE INVOLVEMENT (most primary bone tumors have favored sites within long bones; this may provide a clue to diagnosis). Diaphyseal intramedullary lesions:Favored location for Ewings sarcoma, lymphoma, myeloma. Common for fibrous dysplasia and enchondroma Metaphyseal lesions centered in the cortex:Classic location for a non-ossifying fibroma (NOF). Also, a common site for osteoid osteoma.Epiphyseal lesions:Chondroblastoma (Ch) and Giant Cell Tumor (GCT) are almost invariably centered in the epiphysis. Metaphyseal exostosis:OsteochondromaMetaphyseal intramedullary lesions: Osteosarcoma is usually centered in themetaphysis. Chondro-sarcoma and fibrosarcoma often present as metaphyseal lesions. Osteoblastoma, enchondroma, fibrous dysplasia, simple bone cyst, and aneurysmal bone cyst are commonin this location. Diaphyseal lesions centered in the cortex:Adamantinoma, osteoid osteoma 第3页/共16页 AGE (probably the most important clinical clue). Age group Most common benign lesions Most common malignant tumors 0 - 10 simple bone cysteosinophilic granuloma (嗜酸性肉芽肿) Ewings sarcomaleukemic involvementmetastatic neuroblastoma 10 - 20 non-ossifying fibromafibrous dysplasiasimple bone cystaneurysmal bone cystosteochondroma (exostosis)osteoid osteomaosteoblastomachondroblastomachondromyxoid fibroma osteosarcoma,Ewings sarcoma, adamantinoma 20 - 40 enchondroma giant cell tumor chondrosarcoma 40 above osteoma metastatic tumorsmyelomaleukemic involvementchondrosarcomaosteosarcoma (Pagets associated)MFHchordoma 第4页/共16页 IntroductionChondrosarco