omega3调控多耐药蛋白 胆固醇代谢.pptx

工作汇报;药大共识期刊：生命科学顶尖期刊;The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters in multidrug resistance of colon cancer, is increased by cholesterol in plasma membrane and detergent resistant membranes (DRMs) [血浆胆固醇和膜蛋白]. ;F1. Effects of ω 6PUFAs and ω 3PUFAs on cholesterol synthesis and cells viability in colon cancer cells.;2. ω3PUFAs reduce HMGCoAR expression in colon chemoresistant cancer cells by increasing its ubiquitination（泛素化）;F3. Effects of ω3PUFAs on HMGCoAR transcription, phosphorylation and ubiquitination in colon cancer cells;F4 ω 3PUFAs increase the ubiquitination of HMGCoAR by activating the E3 ligase Trc8.;F5 Effects of ω3PUFAs on cholesterol and ABC transporters in whole cell and DRMs.;ω3PUFAs sensitize multidrug-resistant colon cancer cells to the antitumor effects of Pgp and MRP1 substrates;【Highlights】;【Why】;文献汇报;【Inspirations】;感谢大家观看！