Gd-EOB-DTPA动态增强MRI与超声造影对肝癌射频消融术后.doc

Gd-EOB-DTPA动态增强MRI与超声造影对肝癌射频消融术后疗效评估的对比研究 王玉婷 李晓明 黄成玲 程琳 赵俊 谢巧 张琳 第三军医大学西南医院放射科 400038重庆 通讯作者：张琳 zhanglinxm@ 目的：通过与超声造影比较，探讨Gd-EOB-DTPA动态增强MRI评估肝癌射频消融治疗后肿瘤存活以及新增病灶的价值。 方法：本研究回顾性分析我院30例射频消融治疗后的肝癌患者。所有患者均接受超声造影检查和Gd-EOB-DTPA动态增强MRI的两种检查。比较两种检查方法对肝癌射频消融术后病灶的活性及肝内新发病灶的敏感性、特异性和准确性。 结果：Gd-EOB-DTPA动态增强MRI诊断残存肿瘤的敏感度、特异度及准确度分别为90.9%、93.0%及80.0%，而超声造影诊断残存肿瘤的敏感度、特异度及准确度分别为45.5%、71.4%及66.7%；Gd-EOB-DTPA动态增强MRI诊断新增病灶的敏感度及准确度分别为93.3%及83.3%，而超声造影诊断新增病灶的的敏感度及准确度分别为50.0%及30.0%。两两比较均具有显著性差异（P0.05）。 结论：对于肝癌RFA术后的患者，在疗效评估方面，不论是对原发病灶残存肿瘤及还是肝内新增病灶的诊断，Gd-EOB-DTPA动态增强MRI均明显优于超声造影，尤其对于小病灶的显示较超声造影敏感得出这一结论的论据从摘要来看似乎不充足。 得出这一结论的论据从摘要来看似乎不充足 关键词：肝细胞癌；射频消融术；Gd-EOB-DTPA；MRI；动态增强； A comparative study on Gd-EOB-DTPA dynamic enhanced MRI and contrast-enhanced ultrasound evaluating hepatic carcinoma after radiofrequency ablation Wang Yuting, Li Xiaoming, Huang Chengling, Cheng Lin,Zhao Jun , Xie Qiao, Zhang Lin． Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038 ,China. Corresponding author: Zhang Lin Email: zhanglinxm@ Objective to study application of Gd-DTPA dynamic enhanced MRI into evaluation of remaining tumor and new lesion after radiofrequency ablation(RFA) of hepatic carcinoma(HCC). Methods to retrospectively analyze 30 patients with HCC after RFA. All the patients underwent contrast-enhanced ultrasound(CEUS) and Gd-EOB-DTPA dynamic enhanced MRI. Both methods detecting post-RFA lesion’s activity were compared, as well as new lesions’ sensitivity, specificity and accuracy. Results the sensitivity, specificity and accuracy of Gd-EOB-DTPA dynamic enhanced MRI detecting the remaining tumors were 90.9%, 93.0% and 80.0%, respectively. The sensitivity, specificity and accuracy of CEUS detecting the new lesions were 45.5%, 71.4% and 66.7%, respectively. The sensitivity and accuracy of Gd-EOB-DTPA dynamic enhanced MRI detecting the remaining tumors were 93.3% and 83.3%, respectively. The sensitivity and accuracy of CEUS detecting the new le