N_Cadherin与急性CO中_省略_迟发性脑病大鼠神经损伤相关性研究.pdf

目 录 摘要 ······························································ ···························· 1 Abstract ······················································ ································ 4 前言 ······························································ ···························· 8 材料与方法 ······························································ ·················· 12 结果 ····························································· ··························· 26 讨论 ····························································· ··························· 33 结论 ······························································ ··························· 37 本研究不足之处 ······························································ ············ 38 参考文献 ······························································ ····················· 39 综述：急性 CO 中毒后迟发性脑病发病机制及脱髓鞘损伤改变相关因子研究 进展 ······························································ ··························· 49 附录 ······························································ ··························· 65 攻读学位期间发表文章情况 ···························································· 66 致谢 ······························································ ··························· 67 个人简历 ······························································ ····················· 69 N-Cadherin 与急性 CO 中毒后迟发性脑病大鼠神经损伤相关性 研究 摘 要 背景 过量的一氧化碳（CO ）气体被人体吸收，不仅会引起急性致命性中毒，还可能 引起急性 CO 中毒后迟发性脑病（delayed encephalopathy after acute carbon monoxide poisoning ，DEACMP ）的发生。脱髓鞘神经损伤是该病的主要病理表现之一，也是本 病预后不佳的重要原因。有报道称 N-Cadherin 或其相关信号通路可以影响少突胶质 细胞的迁移，从而导致脱髓鞘神经损伤修复受阻。说明，N-Cadherin 或其相关信号通 路