3. 医学分子生物学innate immunity.pdf

Innate Immunity The perfect world The real world Bacteria, Fungi, Parasites, Viruses BACTERIA - Clostridium FUNGUS - difficile (causes Epidermophyton antibiotic- floccosum associated (causes athlete’s colitis foot) antibiotic- associated diarrhea) PARASITE - VIRUS- Polio Tapeworm Immunity • The immune system is a bodywide network of cells and organs that has evolved to defend the body against attacks by foreign invaders • Include innate immunity and adaptive immunity Innate and adaptive immunity (The innate responds instantly) The response to an initial infection occurs in three phases Comments  Components of the innate immune response  Features of innate immune recognition  Role of innate immunity Components of the innate immune response * Barriers * Molecules * Leukocytes Skin and mucosa  Mechanical barrier  Chemical barrier  Microbiological barrier Blood-Cerebrospinal fluid barrier 软脑膜、脉络丛 Blood-fetal barrier （基蜕膜） 绒毛膜滋养层细胞 Chorionic trophoblast  Defensins * and defensins * Microbial killing Muramidase (lysozyme) * Microbial killing  Complement Functions of complement Other effector proteins  Reactive oxygen intermediate (ROI)  Lipid mediate (LTB4 PG PAF