采用多功能单冲孔压片机预测冲孔形状对平板失效的影响外文文献翻译、中英文翻译.docxVIP

asian?journal?of?pharmaceutical?sciences?12?(2017)?412–417 Available?online?at? ScienceDirect journal?homepage:? w w w. e l s e v i e r. c o m / l o c a t e / a j p s Original?Research?Paper Prediction?of?effects?of?punch?shapes?on tableting?failure?by?using?a?multi-functional single-punch?tablet?press Takashi?Osamura?a,b,?Yoshiko?Takeuchi?a,?Risako?Onodera?a,?Masahiro?Kitamura?b, Yoshiteru?Takahashi?b,?Kohei?Tahara?a,?Hirofumi?Takeuchi?a,* a b Laboratory?of?Pharmaceutical?Engineering,?Gifu?Pharmaceutical?University,?1-25-4?Daigaku-Nishi,?Gifu?501-1196,?Japan Pharmaceutical?Technology?Department,?Sawai?Pharmaceutical?Co.?Ltd,?12-34,?Hiroshibacho,?Suita-Shi,?Osaka?564-0052,?Japan A?R?T?I?C?L?E I?N?F?O A?B?S?T?R?A?C?T Article?history: Received?11?April?2017 Accepted?4?May?2017 Available?online?17?May?2017 Keywords: Tableting Formulation?design Lubricant Punch?shape Single-punch?tablet?press Losartan?potassium We?previously?determined?“Tableting?properties”?by?using?a?multi-functional?single-punch tablet?press?(GTP-1).?We?proposed?plotting?“Compactability”?on?the?x-axis?against “Manufacturability”?on?the?y-axis?to?allow?visual?evaluation?of?“Tableting?properties”.?Various types?of?tableting?failure?occur?in?commercial?drug?production?and?are?in?uenced?by?the amount?of?lubricant?used?and?the?shape?of?the?punch.?We?used?the?GTP-1?to?measure “Tableting?properties”?with?different?amounts?of?lubricant?and?compared?the?results?with those?of?tableting?on?a?commercial?rotary?tableting?machine.?Tablets?compressed?with?a?small amount?of?lubricant?showed?bad?“Manufacturability”,?leading?to?sticking?of?powder?on?punches. We?also?tested?various?punch?shapes.The?GTP-1?correctly?predicted?the?actual?tableting?results for?all?punch?shapes.?With?punches?that?were?more?likely?to?cause?tableting?failure,?our?system predicted?the?effects?of?lubricant?quantity?in?the?tablet?formulation?and?the?occurrence?of sticking?in?the?rotary?tableting?machine. ??2017?P