APOE基因与认知障碍.ppt

ApoE的氨基酸序列的112位和158位两种氨基酸残基即精氨酸（Arg）和半胱氨酸（Cys）的交换决定了异构体的种类。ApoE4在这两个位置上都是Arg；E2都是Cys；112位为Cys和158位是Arg者为ApoE3异构体，自然人群中，基因频率ε3分布最高，ApoE3/3表型分布约70%。Cys半胱氨酸 “Standards of Medical Care in Diabetes—2014” comprises all of the current and key clinical practice recommendations of the American Diabetes Association (ADA) These Standards of Care are revised annually by the ADA’s multidisciplinary Professional Practice Committee (PPC) For the current revision, PPC members systematically searched Medline for human studies related to each subsection and published since 1 January 2013 Recommendations were revised based on new evidence or, in some cases, to clarify the prior recommendations or match the strength of the word to the strength of the evident A table linking the changes in the recommendations to new evidence can be reviewed at /CPR As for all position statements, the Standards of Care were reviewed and approved by the Executive Committee of ADA’s Board of Directors, which includes health care professionals, scientists, and lay people Feedback from the larger clinical community was valuable for the 2014 revision of the Standards of Care; readers who wish to comment on the “Standards of Medical Care in Diabetes—2014” are invited to do so at /CPR ADA funds development of the Standards of Care and all ADA position statements out of its general revenues and does not use industry support for these purposes The slides are organized to correspond with sections within the “Standards of Medical Care in Diabetes—2014” While not every section in the document is represented, these slides do incorporate the most salient points from the Position Statement * Reference American Diabetes Association. Standards of medical care in diabetes—2014. Diabetes Care 2014;37(suppl 1):S1 “Standards of Medical Care in Diabetes—2014” comprises all of the current and key clinical practice recommendations of the American Diabetes Association (ADA) These Standards of Care are revised annually by the A