粒血康胶囊治疗慢性粒细胞白血病的临床及实验研究-中西医结合内科专业论文.docxVIP

Y《8《《2 Y《8《《2 7 提 要 本研究经过3年的临床观察，并通过动物实验、体外研究，对粒血康胶 囊加化疗治疗慢性粒细胞白血病的临床疗效及作用机理进行了分析，发现粒 血康加化疗治疗CML优于单纯化疗组，完全缓解率为77．78％，总缓解率为 94．44％，优于对照组(PO．05)；粒血康胶囊可迅速降低CML肿瘤负荷， 缩脾效果亦明显优于对照组，还可改善患者的生存质量，对头晕、乏力、嗜 睡、多汗、纳呆、腹胀、发热的症状消失率明显高于对照组，并可提高患者 的红细胞免疫，此外还分析了中医证型与疗效预后的关系。动物实验证实粒 血康胶囊可延长L6，，自血病小鼠的生存期，并对化疗药物有协同增效的作 用。体外实验采用血清药理学方法证实粒血康胶囊药血清可显著抑制K562、 HL一60细胞增殖，并诱导细胞凋亡，还可影响白血病细胞周期的分布，降低 s期比率，将细胞阻滞于G#M期。 i研究表明粒血康胶囊对化疗有协同增效作用，并可通过增强患者红细胞 免疫以及诱导自血病细胞凋亡而发挥治疗CML的作用。 主题词：惶丝塾塑堕自查寥／中亘廷结金痘这趋垒康腔囊，隧盒也f丝 鲤堕丝缨啦 ClinicaI ClinicaI and Experimental Research of Capsule LiXueKang on Chronic Myelogenous Leukemia Speciality：Oncology,Hematology Student：Cao Fang Tutor：Prof．Tang Youjtin Abstract Through clinical observations of three years，animal experimems and research in leukemia cells，the anther analyses the curative effect and mechanism of Capsule LiXueKang and finds that LiXueKang combined with chemotherapy has notabal curative effect，the rate of CR is 77．78％，the total effective rate is 94．44％．which is better than that of the control group(PO．05)．Furthermore， Capsule LiXueKang can lighten the tumor bad of CML immediantly．It can also reduce the spleen obviously,which is better than that in the control group．At the same time．it can improve the existent conditions ofpatiems and get rid ofsome of the symptoms such as swirl，tired，somnolence,hyperhidrosis，anorexia，abdominal flatulence and fever et．It call also enhance the immuno-function oferythrocytes i11 CML patients．The auther has analysed the relationship herren the curative effect disease‘s types in TCM．The animal experiments approve that LiXueKang could prolong the survival time of L6Is leukemia rats and improve the curative effect of chemotherapy．With the method of serum pharmacology,the auther fmds that the serum of LiXueKang could significently restrain the multiplication of K562 and HL一60 cells and it depends on its concentration of serumJt could induce apoptosis．Moreover it could affect the distribution of ce】lular cycle,debase the rate ofcy