药源性血栓栓塞症.pdfVIP

药塑丕＆区廑盘查!Q!堡生!旦筮!!鲞筮!翅垒望堕：塑!型!翌!!!!：!生!鱼：堕!：! ．综述． 药源性血栓栓塞症 杨文君徐翔 【摘要】 药源性血栓栓塞症是指因某些药物使血管内血栓形成和／或栓塞并导致组织和器官功 能受损的疾病。药源性血栓栓塞症的发病机制主要为血管内皮细胞损伤、血液成分改变和血流动力 学异常。导致血栓栓塞症的常见药物有造影剂、化疗药、免疫抑制剂、免疫增强剂、环氧化酶2抑制 剂、抗精神病药和激素等。药源性血栓栓塞症以门静脉、脾静脉、肾静脉或脑静脉窦等深静脉血栓形 成较常见，动脉血栓较为少见。药源性血栓栓塞症可应用普通肝素、低分子肝素、磺达肝癸钠、华法 林、尿激酶、阿替普酶、阿加曲班、重组水蛭素或达那肝素钠治疗。 【关键词】栓塞和血栓形成；药源性疾病 Affiliated Drug-inducedthromboembolism№ng耽咖n，舰Xiang．DepartmentofPharmacy，Second School 310009，China HospitalofZhejiangUniversityofMedicine，Hangzhou author：Xu CorrespondingXiang，Email：xytxu@126．com ，11}Ietermof thromboembolismreferstointravascularthrombosisand／or 【Abstract】 drug—induced thromboembolismdueto and in tissueand function．r11Iemainmechanismsof drugsresultingimpaired organ thromboembolisminvolve ofendothelial ofblood and cells，the drug—induced injury change components includecontrast whichcausethrombosis hemodynamicabnormality．Drugs mainly media，chemotherapeutic agents，immunosuppressiveagents，immunopotentiators，cyclooxygenase-2inhibitors，antipsychoticagents， andhormones．r111emostcommon thrombosisis veinthrombosissuchas vein． drug—induced deep portal vein．renalvein．orcerebralvenoussinus．Arterialthrombosisisless splenic common．Drug．induced COuldbetreatedwith molecular thrombosis unfractionated weightheparin，fondaparinux heparin，lOW hirudinor sodium． sodium，warfarin，urokinase，alteplase，argatroban，recombinantdanaparoid Embolismand diseases 【Keywords】