课件：HE4 崔恒 北京大学人民医院.ppt

ROMA? has increased sensitivity compared with RMI Pre PostMenopausal Benign (n = 315) vs EOC (n = 124) Sensitivity* (95% CI) Specificity (95% CI) RMI 85% (77% to 90%) 75% (70% to 80%) ROMA? 94% (89% to 98%) 75% (70% to 80%) Benign and EOC: All Stages *Two Sample Test of Equality of Proportions p=0.0129 CI: Confidence Interval ROMA? Has Increased Sensitivity vs RMI For Early Stage Cancer Pre PostMenopausal Benign (n=315) vs Stage I-II EOC (n=35) Sensitivity* (95% CI) Specificity (95% CI) RMI 66% (48% to 81%) 75% (70% to 80%) ROMA? 86% (70% to 95%) 75% (70% to 80%) Benign and EOC: Stage I II *Two Sample Test of Equality of Proportions p=0.0510 CI: Confidence Interval 表 患者被ROMA划分为高危组和低危组的分布 月经状态 疾病 高危(例 ) 低危(例) 合计(例) 敏感性(%) 特异性(%) PPV (%) NPV (%) 绝经后 恶性 35 2 37 EOC 28 0 28 良性 4 8 12 合计a 32 8 40 100.0 66.7 87.5 100.0 合计b 39 10 49 94.6 66.7 89.7 80.0 绝经前 恶性 12 4 16 EOC 8 0 8 良性 23 103 126 合计a 31 103 134 100.0 81.7 25.8 100.0 合计b 35 107 142 75.0 81.7 22.9 96.3 全部 恶性 47 6 53 EOC 36 0 36 良性 27 111 138 合计a 63 111 174 100.0 80.4 57.1 100.0 合计b 74 117 191