chapter26　antivirul drugs.pptx

Chapter 22 Clinical application of antiviral drugs;Learning guide;1. Overview General conditions of viral infection and antiviral drugs The main target and mechanism of antiviral drugs 2. Antiviral drugs and their clinical applications Antiviral drugs for the treatment of respiratory diseases Antiviral agents for the treatment of viral hepatitis Antiviral agents for the treatment of herpes virus and cytomegalovirus infection Anti HIV drugs;Virus infection：About 75% of human infectious diseases are caused by virus, which seriously endanger human health with influenza, HIV / AIDS, viral hepatitis, encephalitis, poliomyelitis, measles, smallpox, rabies, sars. Chemotherapeutic drugs：At present, most of the anti viral drugs used in clinical practice are mostly toxic, and the clinical curative effect needs to be improved. Immunotherapy：In the history of medicine, It has successfully used vaccination methods to prevent the terrible epidemic of infectious diseases (such as smallpox, measles, poliomyelitis, rabies, etc)。 Effect of biological agents in viral infection：Vaccine, interferon and interferon inducer and so on in the treatment and prevention of viral infectious diseases still occupies a very important position. ;In 1555, 2 million people died in the Mexico smallpox epidemic. In 1919 Worldwide, 20 million people died of influenza . 1976 Ebola virus appeared in the African continent; in 1981 AIDS appeared , SARS in 2003, the arrival of the SARS coronavirus, which made people unprepared; In 2009 Influenza a H1N1 virus pandemic 2010 EV71 intestinal virus caused hand foot mouth disease.;Section One outlines ;Section One outlines ;第一节 概述;第一节 概述;第一节 概述;1.Less selective antiviral drugs The virus does not have a cell wall or membrane. Virus is a parasitic microorganism living cells, can not be carried out outside the living cells. The virus must be replicated in the host cell by the host metabolic mechanism. Many antiviral drugs interfere with the replication of the