血清VEGFCA125与βHCG在异位妊娠治疗中价值.docVIP

血清VEGFCA125与βHCG在异位妊娠治疗中价值 　　【摘 要】 目的:探讨联合监测血清血管内皮生长因子、血清糖类抗原(CA125)和血绒毛膜促性腺激素(β-HCG)在异位妊娠治疗中的价值。方法:对50例EP患者(分为药物保守治疗组A组,手术治疗组B组)治疗前后的CA125、β-HCG、VEGF水平进行联合监测。结果:异位妊娠患者A组治疗前后比较:β-HCG、VEGF治疗后下降,CA125治疗后升高,差异有显著性意义。B组治疗前后比较:β-HCG、VEGF治疗前后明显下降,CA125治疗后明显升高,差异有显著性意义。B组治疗前β-HCG、VEGF明显高于A组,而CA125低于A组,差异有显著性。结论:联合监测血清VEGF、CA-125与β-HCG的指标在异位妊娠治疗中有重要的意义。 　　【关键词】 异位妊娠(TP);CA125;β-HCG;VEGF 　　 　　Value of Serum VEGF, CA-125 and β-HCG in treatment of ectopic pregnancy 　　HAO Yuwen, WANG Qian, WANG Kun, LI Jinye, LI Yang, HAN Siyang 　　Daqin Longnan Hospital, the Fifth Affliated Hosptial of Qiqi Haer Hospital, Daqin 163453, China 　　【Abstract】 Objectives: To explore the value ofJoint monitoring of serum carbohydrate antigen (CA125) and blood human chorionic gonadotropin (β-HCG) and serum vascular endothelial growth factor on thetreatment of ectopic pregnancy. Methods: Fifty patients with EP (They are randomly divided into conservative drug treatment group A, surgical treatment group B) were monitored before and after treatment for their CA125, β-HCG, VEGF levels. Results: The results indicated that β-HCG, VEGF level decreased, and CA125 increased after treatment in both group A and B, and the difference being significant. Pre-treatment β-HCG, VEGF level of Group B was significantly higher than that of group A, while CA125 level was significantly lower than the group A. Conclusion: Joint monitoring of serum VEGF, CA-125 and the target β-HCG level is important in the treatment of ectopic pregnancy. 　　【Key words】 Ectopic pregnancy; CA-125; β-HCG; VEGF 　　 　　异位妊娠是妇科常见急腹症。近年来,异位妊娠(EP)的发病率呈明显上升趋势,目前占妊娠总数的2%。诊断技术的提高使得EP向着诊断早、准确率高的方向发展,EP的误诊、漏诊的几率减少,这也是EP的发生率上升的原因。随着对保留生殖能力的重视,保守治疗已成为EP治疗的主要手段。本文探讨血清VEGF、CA-125与β-HCG联合监测在EP治疗中的价值。 　　 　　1资料与方法 　　 　　1.1 研究对象 　　2007年1月~2008年12月,入选标准要求患者月经周期规律,入院时临床表现支持未破裂异位妊娠,生命体征平稳,没有或只有少量腹腔内出血。行开腹或腹腔镜切除输卵管的患者,术前行药物治疗者及既往有子宫内膜异位症患者不作为研究对象。符合条件的有50例,年龄22~40岁,停经34~60天,其中10例行腹腔镜手术,9例开腹手术,其余31例行米非司酮+甲氨蝶呤保守治疗。药物保守治疗组为A组,主要根据:患者无药物禁忌症,无明显内出血,血B-HCG0.0