牛海绵状脑病_2课件.ppt

狂牛病的警訊 周晉澄 Chin-Cheng Chou, DVM, Ph.D. 國立台灣大學獸醫學系教授 Institute of Veterinary Medicine National Taiwan University Taipei, Taiwan chouchin@ntu.edu.tw 02 02專業目的 畜產業生產人類食用的優質動物性蛋白，獸醫則確認各種動物的健康及動物性產品的安全與衛生 獸醫畜產環境 各類型經濟動物養殖場: 豬、牛、 羊、鹿、兔、雞、鴨、鵝、魚、 蝦、甲魚、牛蛙等; 野生動物園; 寵物畜養場; 動物醫院; 屠宰場、化製廠等 獸醫畜產環境公害 旨揭該環境引起人們不愉快之感受，即構成公害的條件。這些感受可能經由空氣、水、廢棄物等途徑引起，不悅的感受不一定必須以引起疾病之有無作為判斷的依據。獸醫畜產環境的維護在於公共衛生的認知，尤其是獸醫公共衛生的充分發揮。 獸醫公共衛生Veterinary Public Health Veterinary Public Health (VPH) was defined by the WHO consultation on future trends in veterinary public health held in Teramo, Italy in 1999 as the sum of all contributions to the physical, mental and social well-being of humans through an understanding and application of veterinary science. -- 即以獸醫科技來促進人類的身心健康福祉！ 牛海綿狀腦病 (BSE) -- 養牛業與化製業的噩夢 Known as Human Mad Cow Disease (人類狂牛病) or new variant Creutzfeldt-Jakob disease(vCJD; 新型庫賈氏病) Long incubation period of 5 to 20 years (May be more than 50 years – The Lancet, 367: 2068-74, 2006) 217 vCJD patients (1996-2009. 10) 11 countries: UK 170, France 25, Spain 5, Ireland 4, USA 3, Netherlands 3, Portugal 2, Italy 2, 1 each in Canada, Japan and Saudi Arabia  Bovine Spongiform Encephalopathy (BSE) Infectious, progressive neurodegenerative, fatal brain disease in cattle – first identified in 1986 in UK Suspect pathogen: Accumulation of protein infectious particle PrPSC (normal cellular prion protein普利昂蛋白PrPC converted into PrPSC) in nervous tissue Incubation period of 20 months to more than 10 years before showing ataxia, attitude and behavior changes, uncoordinated movements, trouble standing and walking, weight loss clinical symptoms, and may process from 2 weeks to 6 months and dies eventually World Animal Health Situation 25 BSE countries between 1989 and 2009 Austria, Belgium, Canada, Czech Republic, Denmark, Finland, France, Germany, Greece,