星型胶质细胞在不同接触状态下,cyclina cyclind1与p27表达分析-analysis of cyclina cyclin d1 and p27 expression in astrocytes under different contact conditions.docx
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星型胶质细胞在不同接触状态下,cyclina cyclind1与p27表达分析-analysis of cyclina cyclin d1 and p27 expression in astrocytes under different contact conditions
celldifferentiationanddeath;thesametime,cellcycleregulationhasmanyimportantphysiologicalfunctionsandacrucialrole.Therefore,wehavereasonstobelievethattheremaybecontrolofthegradualprogressofthecellcyclethroughtheentireperiodofcellgrowthanddevelopment.Thecellcycleregulatoryproteinsisnuclearproteinwhichinterrelatedconstraintsofdifferentfunctions,accordingtotheroleofcellcyclecontrolproteins,itcanbedividedintocellcyclecontrolproteins(includingCyclin,CDK,andpRb)andcellcyclenegativecontrolproteins(CKIfamily).Asagroupofproteinwithcyclicchangesintheappearanceanddisappearance,cellcycleproteins(Cyclin)arewiderangeofmoleculeswhichcontrolledthecellcycleeukaryoteingfromyeasttohumans.TheregulationofCyclinplaysanimportantroleinthenormalcellcycle.Currently,thereare20kindsofCyclinfoundinmammaliancells.AclearregulationofthecellcycleismainlyCyclinA,B,C,DandE,Cyclinmoleculesarehighlyconservedevolutionarily,whichmolecularstructurehasaCyclinboxsequence,CyclinandCDKcombinedintocomplexregulatingofcellcycleorplayingthefunctionoftranscription;ThecontentofCDKisrelativelyconstantinvariousstagescellcycle,theactivityofCDKisdependentontheregulationofCyclin.CDKmustbecombinedwiththecorrespondingofCyclinandhadactivityorinactivitydepentonphosphorylationordephosphorylationinthecertainparts,Cyclinandrelatedmoleculesofcellcycleregulationishotspotsintheresearch.Negativecellcyclecontrolprotein(CKIfamily),includingP21,P27,P57,etc.,caninhibitactivityofmostknownCyclin-CDKcomplexkinase,andplayimportantroleontheearlyandlateG1phase,Sphaseandotherphase,theCKI,whichdistributionandfunctionvaryindifferentcells,isthemainstudyinnowadays.Toexaminethemechanismsofcontactinhibition,wechosethreetypesofcellcycleassociatingproteinwithCyclinA,CyclinD1andP27asamarkertoobservethemintheprocessofproliferationandinexpressionofcontactinhibition,anddiscusstheinteractionbetweenthecontactinhibitionandcellcycleregulation.Inthisstudy,wedetectexpressionofCyclinA,CyclinD1andP27proteinunderthesemi-convergencestateandconfluencestateofastrocy
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