新余市渝水区门诊帕金森病相关危险因素分析-analysis of risk factors related to parkinsons disease in out-patient clinics of yushui district, xinyu city.docx

ABSTRACTObjective:Toexplorethepotentialassociationbetweenheavyindustrypollutionandriskofparkinson’sdisease(PD)andfurtherinvestigatetheimpactofotherfactorsonPD.Someevidenceswould,consequently,beprovidedonPDprimarypreventioninXinyu.Methods:Weconductedahospitalbasedcase-controlstudyofPDinthespecificoutpatientsHospital.CasesoflocalpatientswithPDfrom2013-2014inXinyupeople’shospitalwereselectedastheobservationgroup,casesoflocalvolunteerswithoutPDascontrolgroup(control/caseratio=1).Allcaseswereinterviewedbyaquestionnaire.Thefollowingcharacteristicswereincluded:geographicalanalysis,agedistribution,gender,lifestyle,educationlevel,familyhistory,medicalhistory,diagnosisandtreatmentofenrolledsubjects.Results:Heavyindustrypollutionandmetalexposure(OR=1.47,95%CI=0.62-3.46，P=0.38)werenotassociatedwithPD(OR=1.48，95%CI=0.61-3.47,P=0.39).Thereweresignificantdifferencesofsmokingintwogroups(OR=0.41,95%CI=0.21-0.92),smokingwasaprotectivefactor.PesticideusewasariskfactorforPD(OR=2.95,95%CI=1.45-5.89).TheoccurrenceofPDwasrelatedtocollegeeducation(OR=0.23,95%CI=0.11-0.60).ThehighereducationlevelwasariskfactorofPD.FamilyhistorywasariskfactorforPD(OR=0.31,95%CI=0.15-0.68).LogisticregressionanalysisshowedthatsmokinganddrinkingteawasnegativecorrelationwithPD.Theriskofsmokerswasalmosthalfasnon-smokers(OR=0.537).TheincidenceofPDinteadrinkerswas1/5innoteadrinkers(OR=0.200).Theage(P=0.033)andgender(P=0.010)wereriskfactorsofPD,otherfactors(occupationaldistribution,alcohol)hadnoassociationwithPD.SurveydatashowedthatthemisdiagnosisrateofPDwashigh.35%ofPDwasmisdiagnosedascervicalorlumbarvertebradisease.Conclusions:IndustrypollutionisnotassociatedwiththeriskofPD.SmokinganddrinkingteamaydecreasetheriskofPD.Pesticide,collegeeducation,familyhistory,ageandgendermayincreasetheriskofPD.TheotherfactorsincludedprofessionanddrinkinghavenorelationtotheoccurrenceofPD.ThemisdiagnosisrateofPDwashigh.35%ofPDwasmisdiagnosedascervicalorlumbarvertebradisease.Keywords:Xinyucity,ks’sDisease,Riskfactor.目录第1章引言............