化学糖生物学金属离子探针宣讲培训.ppt

化学糖生物学;*;*;什么是化学糖生物学？;化学糖生物学主要研究内容;“预活化”一釜寡糖合成;聚合物支载的寡糖合成（包括含氟链、离子液等）;固相寡糖合成技术;酶法或化学-酶法合成寡糖;寡糖合成方法的研究;Jin-Hwan Kim, Hai Yang, Jin Park, and Geert-Jan Boons, J. Am. Chem. Soc. 2005, 127, 12090-12097.;;离去基;二、糖缀合物的合成;Chemical site-selective protein glycosylation;Chemoenzymatic approach for homogeneous N-glycoproteins;Withers, et al. Angew. Chem. Int. Ed. 2006, 45, 2585.;Chemical Synthesis of Glycopeptides and Glycoproteins;Carbohydrate Microarrays; ;;;Biosynthesis of glycans;Bioorthogonal chemical reporter strategy;Bioorthogonal chemical reactions;Cell-selective labeling based on targeted liposomes;enrichment with streptavidin beads;Proteomic analysis of tumor sialylglycoproteins;A FRET-based method for protein-specific glycan imaging;Dual labeling of a specific receptor;Direct Raman imaging of glycosylation;SERS detection of SiaNAl on cell surfaces;“Sweet Heart”: Visualizing cardiac glycome in intact hearts;Sialylation is upregulated in hypertrophy ;用化学-酶标记策略分离鉴定O-GlcNAc修饰的蛋白;;基于糖单层的细胞表面糖基原位电化学检测;*;Some Iminosugar-Based Drugs;选择蛋白(selectin)的一种天然寡糖配体SLex;糖组装物与多价效应;某些唾液酸转移酶抑制剂;基于糖的抗HIV疫苗研究;肿瘤相关糖抗原 TACA;;Horst Kunz and Yan-Mei Li’s work;*;抗体修饰;;抗体修饰策略;;糖化学生物学发展展望;*