105例胃癌患者围手术期血浆胆固醇低密度脂蛋白水平比较分析.docVIP

105例胃癌患者围手术期血浆胆固醇低密度脂蛋白水平的比较分析 　　【摘要】 目的 探讨胃癌患者围手术期血浆胆固醇、低密度脂蛋白水平和与病理关系。方法 2008年1月至2010年1月收治的进展期胃癌患者105例(胃癌组),选取同期与本院手术治疗的良性胃疾病组98例(胃病组)进行围术期血浆总胆固醇水平、低密度脂蛋白水平检测并进行比较。同时与病理分型进行相关性比较。结果 胃癌组和胃病组两组手术前血浆胆固醇、低密度脂蛋白比较P0.05差异无统计学意义。不同分化程度的胃癌患者血浆血浆胆固醇、低密度脂蛋白水平差异有统计学意义。结论 胃癌患者由于肿瘤组织对胆固醇需求增加,导致脂质代谢紊乱,出现胆固醇、低密度脂蛋白减少;胃癌组织恶性度越高,分裂增殖能力越强,对胆固醇的需求也就越多,降低的更明显。? 　　【关键词】 胃癌;围手术期;血浆胆固醇;低密度脂蛋白水平;比较分析?? 　　Compartative analysis of plasma cholesterol and low lipoprotein in gastric cancer patients with perioperative plasma 　　MA Cui-ling.The first people’s hospital of Shangqiu,Henan 476000,China 　　【Abstract】 Objective To investigate the expression of perioperative serum cholesterol, low density lipoprotein levels and with pathology. Methods From January 2008 to January 2010 105 cases of patients with advanced gastric cancer (cancer group), select the year and the hospital treatment of benign gastric diseases, 98 patients (gastric group) for perioperative plasma levels of total cholesterol low density lipoprotein levels detected and compared. Also associated with the pathological classification comparison.Results There were significant difference of plasma cholesterol and low density lipoprotein in the two groups before surgery and there were no significant difference after surgery.Different degrees of gastric cancer patients with plasma cholesterol, low density lipoprotein levels significantly. Conclusion The gastric cancer patients the tumor tissue increased demand of cholesterol, resulting in lipid metabolism, there cholesterol, low density lipoprotein reduction; gastric higher grade, proliferative capacity and higher demand on the more cholesterol, reduce more apparent.? 　　【Key words】 Gastric cancer; Perioperative period; Plasma cholesterol;Low density lipoprotein;Comparative analysis 　　? 　　DOI:10.3760/cma.j.issn 1673-8799.2010.11.10? 　　作者单位:476000河南省商丘市第一人民医院 　　胃癌是最常见的消化道恶性肿瘤,近30年来,其发病率呈下降趋势,但每年的新发胃癌,约占全部恶性肿瘤发病的17.2%,仍居首位[1]。实验肿瘤模型及少数人类肿瘤的初步研究显示,肿瘤细胞的胆固醇摄取、合成和膜含量均有改变;胆固醇的代谢参与了D