高尿酸血症陈育青 课件.ppt

高尿酸血症与慢性肾脏病;;新合成嘌呤600－700mg/day;;;;肾对尿酸的转运;M. T. Le et al . NDT, 2008;JAMA. 1993;270:354-359;高胰岛素血症和尿酸排泄分数下降有关;青春期前 青春期后 老年期;;高尿酸血症;;;溶瘤综合征－急性高尿酸血症，高尿酸尿症;尿酸结石;慢性高尿酸血症肾病Gouty /Chronic Urate Nephropathy;;;;;Glycogen Storage Diseases：glycogenosis type I (Von Gierke disease);Familial juvenile hyperuricemic nephropathy;Advances in Chronic Kidney Disease, 2006;J Am Soc Nephrol. 2003 Kidney Int. 2006 ;Zelikovic_Nephrology Dialysis Transplant_2003;;高尿酸血症;尿酸的排泄与高尿酸血症 如何看待尿酸肾病 高尿酸血症和慢性肾脏病的关系;General population;慢性肾脏病和高尿酸血症;Serum uric acid levels associate with tubulointerstitial lesions in IgA nephropathy;Serum uric acid level is associated with tubulointerstitial lesion in IgA nephropathy with GFR=90ml/min/1.73m2;;;尿酸影响内皮功能;尿酸导致肾损伤;J Am Soc Nephrol 13: 2888–2897, 2002;;;Thank You !