hpv11、hpv6与儿童复发性呼吸道乳头状瘤之间的关系分析word论文.docxVIP

道乳头状瘤侵袭性组与非侵袭性组中HPV11、HPV6之间的分布关系，结果P=0.002，差异有统计学意义。结论：（1）儿童复发性呼吸道乳头状瘤侵袭性组中HPV11感染所占比例高，而非侵袭性组中HPV6感染所占比例高。（2）此32例乳头状瘤组织中，HPV11感染12例，HPV6感染20例，检出率100%，符合文献报道。（3）实时定量PCR技术为检测儿童复发性呼吸道乳头状瘤的一种有效方法，可在临床诊断中广泛应用，对患儿做出精确病毒检测。关键词：儿童呼吸道乳头状瘤HPVAbstractObjective:Objectives:ToanalysistherelationshipbetweenHPV11/6and juvenile-onsetrecurrentrespiratory papillomotosis(JO-RRP),weusetheTagmanreal-time quantitativePCRtoidentifyHPVDNA ofthe32patientofjuvenile-onsetrecurrent respiratory papillomotosis .Methonds:Allpatient withJO-RRPwho areenrolledin thisstudy comingfrom a governmenttraininghospitalinlanzhougansuprovinces,after Informed Consent,thelaryngealbiopsiesfrom32childrenwhoallhaveundergonesurgery foreliminatingpapillomotosisaredetectedforHPV11andHPV6usingTagman real-timequantitativePCR.AccordingtoDoylesstandardoftheseverityfor JO-RRP,this32casesareclassifiedintotwocategories:Aggressiveofdiseaseand Nonaggressiveofdisease.Theaimofthisstudyistoanalysisifthereisanypotential associationbetween HPVAtype and the severityof this diseaseResult:Amongthis32patients,theagerangedfrom9monthsto12years.Duringthe follow-up-visit,sixpatientofthischildrentendtoself-curvewithoutanyrecurrenceofthe disease 。But the others are not so lucky ,they have tobear the pain ofreiterantrecurrence of this disease.Across32casesofJO-RRPchildren,12casesareidentifiedasaggressivecourseof thisdisease.Thentherestof20casesareconsiderasnonaggressivecourseofthis disease.9casesofthisseverelaryngealpapillomatosispatientsaredetectedas HPV11infected.17casesofthisnonseverelaryngealpapillomatosisaredetectedasHPV6 infected. A X2test of independence showed statistically significantdifferences between these proportions.(P=0.002) .Conclusions:（1）ForthestudyofrelationshipbetweenHPV11/HPV6withtheseverityof disease , AX2test of independence showed statistically significant differencesbetweentheseproportions.(P=0.002).ShowthatwhenJO-RRPisinfectedwith HPV11,thediseaseistendtomoreattacksandrelapse,whenisisinfectedwith HPV6,disease ten