foxo基因转录活性调控及其对肉品质的影响_王乐_郭月英_程海星_张静_任霆_靳.pdf

网络出版时间：2015-01-26 15:13 网络出版地址：/kcms/detail/11.1759.TS1513.016.html FoxO 基因转录活性调控及其对肉品质的影响 1 王乐，郭月英，程海星，张静，任霆，靳烨* （内蒙古农业大学食品科学与工程学院，内蒙古呼和浩特市010018 ） 摘 要：FoxO 是Fox（Forkhead Box ）转录因子家族的一个亚族，是INS/IGF-1 通路中关键的信号分子。FoxO1 、 FoxO3 、FoxO4 作为FoxO 家族主要成员，通过多种方式调节骨骼肌的生长发育。FoxO 转录因子调控靶基 因的表达、细胞周期进程及程序化死亡，因此FoxO 在成肌细胞增殖分化、肌纤维类型转化及脂肪沉积过 程中发挥重要作用。本文综述了FoxO 基因转录活性调节与骨骼肌发育的相关性，着重介绍FoxO 与肉质相 关基因的相互联系，以期为提高畜肉肉品质提供理论依据。 关键词：FoxO，转录活性，肉质 Regulation of the FoxO transcriptional activity and the affection to meat quality WANG Le, GUO Yue-ying, CHENG Hai-xing, ZHANG Jing, * REN Ting, JIN Ye (College of Food Science of Engineering, Inner Mongolia Agricultural University, Hohhot010018, China) Abstract : FoxO is a subfamily of the Fox (Forkhead Box) family of transcription factors, which is a key signal molecule in INS/IGF-1 pathway. The main members of FoxO subfamily are FoxO 1, FoxO3 and FoxO4,which regulate skeletal muscle development through various pathways. FoxO is a crucial regulatory factor during target gene expression ,process of cell cycle and apoptosis, so FoxO plays an important role in myoblast proliferation and differentiation, the transformation of muscle fiber type, and fat deposition. In this paper, latest advances in correlation of skeletal muscle development and FoxO transcriptional activity were reviewed. The interrelation