艾得辛作用机理及典型病例.pptx

艾得辛作用机理及典型病例中山大学附属第三医院 古洁若教授内容抑制B淋巴细胞产生的免疫球蛋白抑制滑膜细胞多种炎症因子，基质金属蛋白激酶促进成骨细胞分化,防止骨破坏艾拉莫德对CIA大鼠血清IgG和IgM的抑制艾得辛显著抑制小鼠RA滑液组织的IgG和IgM的表达，并呈剂量依赖性。Fang Du, Liang-jing Lü, T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. Arthritis Research TherapyVol 10 No 6 Du et al.Yamamoto T, Aikawa Y, Funaki J, et al. Immunopharmacological studies of a disease-modifying antirheumatic drug iguratimod (T-614); Its effect on immunoglo-blin production and lymphocyte proliferation. Jpn Pharmacol Ther 2007;35:561-9.?艾拉莫德抑制SCID大鼠B细胞产生的IgG和IgM白色: 空白对照组; 浅灰: 0.3 ug/ml；深灰：3 ug/ml ；黑色：30 ug/ml 。Tanaka K, Yamamoto T, Aikawa Y, et al. Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice. Rheumatology (Oxford) 2003;42:1365-71艾拉莫德抑制人B细胞产生的IgG和IgMTanaka K, Yamamoto T, Aikawa Y, et al. Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice. Rheumatology (Oxford) 2003;42:1365-71艾拉莫德显著抑制B淋巴细胞活化、增殖其作用强于MTX和来氟米特艾拉莫德不影响T淋巴细胞增殖 艾拉莫德不影响T淋巴细胞凋亡但MTX显著促进T细胞凋亡小结艾拉莫德抑制B细胞产生的免疫球蛋白IgM和IgG艾拉莫德抑制B细胞的活化和增殖，其作用强于MTX和来氟米特艾拉莫德不影响T细胞活化，增殖和凋亡内容抑制B淋巴细胞产生的免疫球蛋白抑制滑膜细胞多种炎症因子，基质金属蛋白激酶促进成骨细胞分化,防止骨破坏艾拉莫德抑制NF-κB的表达Y. Aikawa et al. Inflamm. res. 51 (2002) 188–194抑制细胞因子产生- IL-6、TNF-α艾得辛与MTX相比，有效抑制血清中IL-6、TNF-α** 与模型组比较P0.01 *与模型组比较P0.05在多项的研究中，艾得辛对多种细胞因子TNFα，IL-6都有显著的抑制作用。Fang Du, Liang-jing Lü, CD Bao :T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. Arthritis Research Therapy (2008) Vol 10 No 6抑制细胞因子产生- IL-4、IL-7与MTX相比，艾得辛有效抑制PBMC中IL-4、IL-17*P＜0.05，**P＜0.01在多项的研究中，艾得辛对多种细胞因子IL-4、 IL-17都有显著的抑制作用。Fang Du, Liang-jing Lü, CD Bao :T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis. Arthritis Research Therapy (2008) Vol 10 No 6若干DMARDs对胶原关