Controlled Drug Delivery - Ning – Create a Social Networking .ppt

Ringcap Technology Based on a tablet (usually film coated) Tablet is partially coated with a series of “rings” Rings can be made of any insoluble polymer that does not erode or degrade during the dispensing period The number of rings, the position of the rings, and the thickness of rings control the rate of release of drug in the final dosage form 09/08/2010 * KLE COP, NIpani Pulsincap Water insoluble capsule body and a water soluble cap Capsule body contains drug and hydrogel polymer capable of rapidly expelling the drug at the predetermined time As the soluble cap erodes, the hydrogel swells and pushes out the drug The hydration rate depends on the hydrogel plug, the length of the plug and the fit ratio (plug diameter to body diameter) 09/08/2010 * KLE COP, NIpani Oral Protein Delivery Nobex Corp. has designed a polymer that binds to specific sites on drug structure to form drug polymer conjugates and allows for oral delivery. Benefits include increased stability in the body, ability to retain normal biological actions, improved efficacy and safety, and increased patient compliance This technology is being used to develop many new products, one of which is oral insulin. 09/08/2010 * KLE COP, NIpani Synthesis of the Drug-Polymer Molecule The polymer blocks enzymes from attacking the protein 09/08/2010 * KLE COP, NIpani Molecular Gates A new gel has been developed that is used to make a “molecular gate” The gel expands at high pH and shrinks at low pH. The gel contains two polymers Polymethacrylic acid Polyethylene glycol 09/08/2010 * KLE COP, NIpani Molecular Gates Adding the enzyme glucose oxidase causes the gel to respond to changes in glucose levels because the glucose and enzyme chemically react to produce an acid. The gates would shrink or open at low pH to release insulin As the glucose levels drop, the pH rises causing the gates to expand and block the release of insulin 09/08/2010 * KLE COP, NIpani Questions? 09/08/2010 * KLE COP, NIpani T