子宫内膜异位症中医证候要素分布特点多元分析.PDF

摇1242 环球中医药2017年11月第10卷第11期摇 Global Traditional Chinese Medicine,November2017,Vol郾10,No郾11 ·数据挖掘 · 子宫内膜异位症中医证候要素分布特点 多元分析 余燚薇摇 赵瑞华摇 张润顺摇 史云摇 王小云摇 刘雁峰摇 王必勤摇 梁瑞宁摇 李伟莉摇 宋 殿荣 揖摘要铱摇 目的摇 探索子宫内膜异位症的中医证候要素分布规律。 方法摇 在多中心、横断面临 床流行病学的基础上采集450例子宫内膜异位症患者临床资料,建立数据库,采用聚类分析和因子 分析方法探讨其证候要素组成及分布规律。 结果摇 经指标聚类分析方法,将82个症状条目聚为28 类,经因子分析,得到24个公因子,初步提取出病位证素4 个:胞宫、肝、肾、脾;病性证素 10 个:气 滞、瘀血、寒、热、湿、痰、气虚、血虚、阳虚、阴虚。 经动态样品聚类分析发现聚为6类时最符合临床, 结合专业知识进行分析,第1~6类分别命名为寒凝血瘀证、湿热瘀阻证、气滞血瘀证、气虚血瘀证、 肾虚血瘀证、痰瘀互结证,其中气滞血瘀证所占比例最大(36.2%)。 结论摇 子宫内膜异位症的病位 在胞宫,与肝、肾、脾相关,病性虚实夹杂,主要证素为气滞、瘀血、寒、热、湿、痰、气虚、血虚、阳虚、阴 虚,中医证型以气滞血瘀证为主。 揖关键词铱摇 子宫内膜异位症;摇 证候要素;摇 横断面研究;摇 气滞血瘀证 揖中图分类号铱摇 R711.71摇 揖文献标识码铱摇 A摇 doi:10郾3969/ j郾issn郾1674鄄1749郾2017郾11郾012 Multivariate analysis of TCM syndromes elements of endometriosis摇 YU Yiwei, ZHAO Ruihua, ZHANGRunshun,et al.摇 Department of gynecology,Guang爷anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China Corresponding author:ZHAORuihua,E鄄mali:rhzh801@126.com 揖Abstract铱摇 Objective摇 To explore the distribution regularity of TCM syndrome elements in endo鄄 metriosis. Methods摇 Based on the multicenter and cross鄄sectional clinical epidemiological investigation, the clinical materials of 450 cases of endometriosis were collected, and the database was establish. Clustering analysis and factor analysis were used to explore composition and distribution law of TCM syndromeselementsinendometriosis. Results摇 Bymeansofindexclusteringanalysismethod,82 symptoms was clustered into28 categories,and 24 common factors were obtained by factor analysis,There were 4 syndrome elements ofdiseaselocations:uterus,liver,kidney,spleen. Thenaturesyndromeelementwere: qi stagnation,blood stasis,cold pathogen,heat pathogen,dampness pathogen,phlegm,qi deficiency, blood deficiency,yang deficiency,yin deficiency. Cluster analysis of dynamic samples showed that the 6 classeswer