肾癌预后.ppt

Why this happens is not entirely clear. Attempts for explanation include the weak activity of EPO produced by the tumor and the low sensitivity to this factor of the tissues involved in the production of blood. The low level and abnormal iron metabolism may play an important role.Thebreakdown of tumor cells in the microvessels has also been described. Growth of inflammatory factors and antibodies that occurs during carcinogenesis may contribute to autoimmune hemolysis.Among the preoperative parameters associated with the red blood cells system, the erythrocyte count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, the rate of the average weight of corpuscular hemoglobin, and the coefficient of variation of volume distribution of erythrocytes (anisocytosis) were analyzed in the study. It has been proven that lowering the value of all the above-mentioned parameters except anisocytosis below a specified cut-off point results in an increased risk of tumor-specific death within the five years of followup. Reduced preoperative values of HGB,HCT,MCV, and MCH also predispose patients to early recurrence of cancer. Similar results were also obtained by other authors [21–24]. 《血小板增多症在肾细胞癌预后评估中的价值》 《外周血血小板增高对肾细胞癌的预后意义》 《恶性肿瘤患者血小板增多的临床意义》 《术前血小板计数与结直肠癌患者预后的关系》 《_妇科恶性肿瘤与血小板增多的关系》 目前血小板对恶性肿瘤预后影响机制的研究主 要集中在促进肿瘤生长和转移两个方面。KUO 等报道血小板激活后释放多种促有丝分裂的活化因 子，这些因子可直接刺激肿瘤细胞生长。KIRWAN 等研究表明活化的血小板可促进 VEGF 的释放， 从而促进肿瘤血管生成利于肿瘤生长。HO-TIN-NOé 等报道血小板可防止炎症诱导的血管损伤，从而 防止肿瘤内出血利于肿瘤生长。另有 JURASZ 等研究显示血小板可使循环中肿瘤细胞逃避机体免 疫系统的攻击，还可保护肿瘤细胞免受血流高剪应 力的损害。MCCARTY 等研究证实血小板参与肿瘤 细胞对血管内皮细胞的黏附。COHEN 等报道血小 板聚集导致血管内皮细胞收缩，从而利于肿瘤向血 管外移行。 谢谢 “ ” BASIC PARAMETERS OF BLOOD COUNT AS PROGNOSTIC FACTORS FOR RENAL CELL CARCINOMA 研究血常规参数做为肾癌的预后因素 研究方法 The study was retrospective and used the medical records of 397 patients who underwent surgery for kidney tumors in our center in the years 2000–2006. During the five-year follow-upperiodofall397patientsoperatedon,230patients with the p