阔叶五层龙的化学成分研究-中国现代应用药学.PDF

Study on Chemical Constituents from Salacia amplifolia PU Jiang1 1,2* 2 1 , FENG Feng , GUO Qinglong , XIE Ning (1.Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; 2.Key Laboratory of Carcinogesis and Intervention of Jiangsu Province, Nanjing 210009, China) ABSTRACT: OBJECTIVE To investigate the chemical constituents of Salacia amplifolia. METHODS The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography, their structures were elucidated by chemical and spectral methods. RESULTS Nine compounds were isolated and their structures was determined as 2- hydroxyfriedelan-3-one (1), friedelin (2), lup-20 (29)-en-3, 21-dione (3), D-friedoolean-14-en-3-one (4), 3-(3′′, 4′′-dihydroxy-trans- cinnamoyloxy)-D-friedoolean-14-en-28-oic acid (5), 3, 22-dioxo-29-normoretane (6), Lupeol (7), β-Sitosterol (8), β-Daucosterol (9). CONCLUSION Compounds 1-9 are isolated for the first time from the plant. KEY WORDS: Salacia amplifolia; chemical constituents; triterpenoids 阔叶五层龙的化学成分研究 濮江 1 1,2* 2 1 ，冯锋 ，郭青龙 ，谢宁 (1.中国药科大学天然药化教研室，南京210009 ；2.江苏省肿瘤发生与干预重点实验室，南京 210009) 摘要：目的 对阔叶五层龙所含化学成分进行研究。方法 应用液-液萃取及多种柱层析方法进行化学成分的分离、纯化， 并利用多种光谱技术进行结构的分析鉴定。结果 从阔叶五层龙植物中分离得到 9 个化合物：2-hydroxyfriedelan-3-one (1) ， 软木三萜酮 (2), lup-20(29)-en-3, 21-dione (3) ，D-friedoolean-14-en-3-one (4) ，3-(3′′,4′′-dihydroxy-trans-cinnamoyloxy)-D- friedoolean-14-en-28-oic acid (5), 3, 22-dioxo-29-normoretane (6), 羽扇豆醇 (7), β-谷甾醇 (8), β-胡萝卜苷(9) 。结论 该 9 个化 合物均为首次从阔叶五层龙中分离得到。 关键词：阔叶五层龙；化学成分；三萜类化合物 中图分类号：R284.1 文献标志码：B 文章编号：1007-7693(2009)11-0916-04 The genus Salacia, belonging to the family and hypoglycemic activit