- 1、本文档共9页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
18FFDG显像在乳腺癌新辅助化疗疗效评价中应用
18FFDG显像在乳腺癌新辅助化疗疗效评价中应用
【摘要】 目的 探讨18FFDG PET显像评价乳腺癌新辅助化疗疗效应用价值。方法 对31例经细针穿刺或针吸细胞活检确诊为原发性乳腺癌的患者在FAC方案化疗前、后分别行18FFDG PET显像,根据PET显像结果计算乳腺癌病灶放射性摄取比值(T/NT);3个疗程结束后评价疗效,以WHO制定的肿瘤化疗评价标准分为有效组[R(+),n=22]和无效组[R(-),n=9];以第3疗程结束后T/NT比值降低百分率≥10%、≥20%、≥30%作为监测治疗有无反应的阈值进行疗效判定。临 床 军 医 杂 志 (Clin J Med Offic)2007年12月 第35卷 第6期结果 化疗前R(+)组和R(-)组T/NT比值分别为3.18±0.41、3.14±0.52(Pgt;0.05),化疗第3疗程后R(+)组T/NT比值从3.18±0.41降低为2.06±0.45(Plt;0.05),而R(-)组T/NT比值从3.14±0.52降低为2.87±0.27(Pgt;0.05);R(+)组T/NT比值降低的百分率为(33.42±6)%,明显高于R(-)组(8.89±6)%(Plt;0.01);若以第3疗程结束后T/N比值降低百分率≥10%、≥20%、≥30%作为监测治疗有无反应的阈值,18FFDG PET评价疗效的灵敏度、特异性分别为100%、89%、82%和85%、92%、100%。结论 18FFDG PET显像对乳腺癌新辅助化疗早期疗效的评价具有一定的临床价值。
【关键词】 18FFDG;乳腺肿瘤;新辅助化疗;疗效
Abstract: Objective To study the application value of response to neoadjuvant chemotherapy in breast cancer using 18Ffluorodeoxyglucose (FDG) positron emission tomography (PET). Methods Thirtyone primary breast cancer patients finally diagnosed by fine needle aspiration examination accepted 18FFDG PET imaging examination before and after three cycles of FAC chemotherapy. Calculation was carried out for the tumortonormal tissue background (T/NT) value in the focus of the cancer. According to WHO criterion, the patients were divided into two groups after therapy, i.e. effective group [R(+), n=22] and noneffective group [R(-), n=9]. According to the T/NT declining percentage (such as≥10%, ≥20% and ≥30%), the patients’curative effects were evaluated respectively.Results The T/NT values of group R(+) and group R(-) were respectively 3.18±0.41 and 3.14+0.52 (Pgt;0.05) before chemotherapy. After chemotherapy the T/NT of group R(+) went down to 2.06±0.45 (Plt;0.05), and the T/NT of group R(-) down to 2.87±0.27 (Pgt;0.05). The declining percentage of R(+) was 33.42%±6%, obviously higher than that of R(-) group (8.89%±6%, Plt;0.05). Based on the declining percentage of T/NT (≥10%, ≥20% and ≥30%), the sensitivity and specificity of 18FFDG PET were 100%, 89%, 82% (sensitivity), and 85%
文档评论(0)