Piperine inhibits cytokine production by human （胡椒碱能抑制细胞因子生产由人类）.pdf

Piperine inhibits cytokine production by human peripheral blood mononuclear cells 1 2 3 S. Chuchawankul , N. Khorana and Y. Poovorawan 1Innovation Center for Research and Development of Medical Diagnostic Technology Project, Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand 2Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand 3Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Corresponding author: S. Chuchawankul E-mail: siriporn.ch@chula.ac.th Genet. Mol. Res. 11 (1): 617-627 (2012) Received August 16, 2011 Accepted January 27, 2012 Published March 14, 2012 DOI /10.4238/2012.March.14.5 ABSTRACT. Piperine, an amide isolated from Piper species (Pipera- ceae), has been reported to exhibit central nervous system depression, anti-pyretic and anti-inflammatory activity. Immunomodulatory and anti-tumor activity of piperine has been demonstrated in mouse car- cinomas. However, there is little information available concerning the effect of piperine on humans. We evaluated the immunophar-