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Piperine inhibits cytokine production by human (胡椒碱能抑制细胞因子生产由人类)
Piperine inhibits cytokine production by
human peripheral blood mononuclear cells
1 2 3
S. Chuchawankul , N. Khorana and Y. Poovorawan
1Innovation Center for Research and
Development of Medical Diagnostic Technology Project,
Department of Transfusion Medicine and Clinical Microbiology,
Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand
2Department of Pharmaceutical Chemistry and Pharmacognosy,
Faculty of Pharmaceutical Sciences, Naresuan University,
Phitsanulok, Thailand
3Department of Pediatrics, Faculty of Medicine, Chulalongkorn University,
Bangkok, Thailand
Corresponding author: S. Chuchawankul
E-mail: siriporn.ch@chula.ac.th
Genet. Mol. Res. 11 (1): 617-627 (2012)
Received August 16, 2011
Accepted January 27, 2012
Published March 14, 2012
DOI /10.4238/2012.March.14.5
ABSTRACT. Piperine, an amide isolated from Piper species (Pipera-
ceae), has been reported to exhibit central nervous system depression,
anti-pyretic and anti-inflammatory activity. Immunomodulatory and
anti-tumor activity of piperine has been demonstrated in mouse car-
cinomas. However, there is little information available concerning
the effect of piperine on humans. We evaluated the immunophar-
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