Sp110基因与肺结核易感相关性研究.pdfVIP

重庆医科大学学报2008年第33卷第4期 (Journal of Chongqing Medical University 2008．Vo1．33 No．4) 一 423一 谗 舞 文章编号：0253—3626(2008)04—0423—05 Spl 10基因与肺结核易感相关性研究 熊 宇，周 丹，陶 杨，李 革 (重庆医科大学公共卫生学院流行病学教研室，重庆 400016) 【摘 要】目的：研究Spl10基因rsl135791、rs722555、rsrs3948464位点基因多态性与重庆市汉族人群肺结核发病的 关系。方法：采用病例对照研究设计，检测rsl135791、rs722555、rsrs3948464位点SNP多态性，用SAS软件进行显著 性检验。结果：(1)Spl10基因rsl135791 CT基因型、rs722555 GG基因型、rsGG基因型、rs3948464 CC基因型在病 例组的频率明显高于对照组；(2)病例组rsl 135791 C等位基因、rs722555 G等位基因、rslG等位基因、rs3948464 c等位基因频率都高于对照组，差异有统计学意义。结论：rsl135791 C／T、rs722555 A／G、rsA／G、rs3948464 C／T可能 是重庆市汉族人群肺结核易患的危险因素。 【关键词】Spl10基因；肺结核 【中国图书分类法分类号】R181．3+3 【文献标识码】A 【收稿日期】2007—10—24 Association between Spl 1 0 gene and susceptibility to tuberculosis XIONG Yu，et ol (Department of Epidemiology，College of Publw Health，Chongqing Medical University) 【Abstract】Objective：To study the association between rsl135791、rs722555、rsrs3948464 polymorphisms of Spl10 gene and susceptibility to tuberculosis of Han people in Chongqing．Methods：Using case—control study，rsl135791、rs722555、 rsm3948464 polymorphisms of Spl10 gene were detected．The test of significance was performed with the computer pmgram，SAS Version 8．2．Results：(1)The frequencies of rsl135791 CT、rs722555 GG、rsGG、rs3948464 CC had statistically significant difference between the case and the control group．(2)The frequencies of rsl 135791 C allele、rs722555 G allele、rsl 1679983 1 G allele、rs3948464 C allele had statistically significant difference between the case and the control group． Conclusion：The rsl135791 C／T、rs722555 MG、rsA／G rs3948464 C／T polymorphisms of Spl10 gene were possibly susceptible to the tuberculosis of the Han people in Chongqing． 【Key words】Spl 10 gene；Tuberculosis 经过大范围流行病学调查显示，结核