MAOP方案治疗初治成人急性淋巴细胞白血病的疗效分析.pdfVIP

天津医药2008年4月第36卷第4期 273 MAOP方案治疗初治成人急性淋巴细胞白血病的疗效分析 薄 剑 王全顺 李红华 赵 瑜 靖 或 于 力 摘要 目的：探讨MAOP方案治疗初治成人急性淋巴细胞白血病(ALL)的疗效及特点。方法：比较分别用MAOP 方案和DOLP方案治疗的36例和32例初治ALL的缓解率及白细胞和血小板减少情况。结果：MAOP方案组29例 达完全缓解(CR率为80．6％)，2例达部分缓解(PR率为5．6％)；总有效率为86．1％。该化疗方案的不良反应主要表现 为不同程度的骨髓抑制、消化道症状以及轻度肝功能异常等，无严重不可逆的脏器功能损害发生。与DOLP方案组 比较，完全缓解率差异无统计学意义(P0．05)，但在白细胞和血小板减少平均持续时间方面要短(P0．05)。结论： MAOP方案诱导治疗初治成人急性淋巴细胞白血病，具有缓解率高、骨髓抑制时间短、患者耐受性好等优点，可作为 诱导缓解成人急性淋巴细胞白血病的备选方案之一。 关键词 白血病，淋巴细胞，急性 药物疗法 成年人 米托蒽醌 阿糖胞苷 长春新碱 泼尼松 Overview of Therapeutic Effectiveness of MAOP Regimen on I nitial Treatment for Acute Ly m- phoblastic Leukemia Patients BO Jian，WANG Quanshun，LI Honghua，ZHAO Yu，JING Yu，YU Li Department ofHematology，ChinesePeople sL沾er 幻nArmyGeneralHospital，Beijing100853，China Abstract Objective：To evaluate the therapeutic effectiveness of MAOP regimen on initial treatment for adult acute lymphoblastic leukemia patients．Methods：Thirty-six new diagnosed acute lymphoblastic leukemia patients were initially treated with MAOP regimen and evaluated the results．Results：Twenty-nine patients got complete remission (CR)with the CR rate of 80．6％．Two patients got partial remission (PR)with the PR rate of 5．6％．The total effective rate was 86．1％． Adverse reactions of this regimen included bone marrow depression，digestive symptoms，and light dysfunction of liver． Compared to the 32 patients with new diagnosed acute lymphoblstic leukemia who accepted DOLP chemotherapy regimens，no inconvertible organ functional lesions were found in MAOP regimen patients．There were no statistic differences in CR rate between these two regimen groups．But the durations of thrombocytopenia and leukopenia were shorter in MAOP group than those ofDOLPgroup(P0．05)．Conclusion：As anin