紫杉醇联合顺铂治疗中晚期食管癌的近期临床疗效.pdfVIP

实用医技杂志2007年11月第l4卷第33期(旬刊) JPMT，November．2007 Vo1．1 No． ( !! ! 盟 !璺芏 ·4533· 紫杉醇联合顺铂治疗中晚期食管癌的近期临床疗效 尹岩伟 ，赵文静 (1．临沂市人民医院，山东临沂276000；2．临沂市肿瘤医院，山东临沂276000) [摘 要]目的：观察紫杉醇联合顺铂治疗复发转移中晚期食管癌的近期疗效及不良反应。方法：36例复发转移 食管癌患者分为两组：紫杉醇+顺铂组18例：紫杉醇150 mS／m2，静脉点滴，第1天；顺铂20 mrCm ，静脉点滴 第2．天 至第5天。5．氟尿嘧啶+顺铂组18例：5一氟尿嘧啶500 ms／m ，静脉点滴，第1天至第5天；顺铂20 ms／m=，静脉点滴， 第2天至第5天，两组均21 d为一周期。结果：紫杉醇+顺铂方案治疗l8例食管癌患者的有效率为66．7％；5一氟尿嘧 啶+顺铂组治疗18例食管癌患者的有效率为33．3％。两组比较差异有显著性。但紫杉醇+顺铂组的化疗毒副反应 较重，主要为白细胞减少和血小板降低。结论：紫杉醇联合顺铂治疗复发转移食管癌近期疗效显著，值得临床应用，但 要防治其严重的毒副反应。 [关键词]紫杉醇；顺铂；食管癌 [中图分类号]R735．1 [文献标识码]A [文章编号]1671-5098(2007)33-4533-02 Clinical Observation of Paclitaxel and Cisplatin for Advanced Oesophageal Cancer YIN Yan—Wei ．ZHAO Wen—Jing (J，Liny／n People’Hospital，Linen，Shandong 276000，China； 2，Linyin Turmor Hospital，tinyin．Shandong 276000，China) Abstract：Objective To observe the recent effect and toxicity of Paclitaxel(PTX)and Cisplatin(DDP)for advanced Oe． sophageal cancer，Methods 36 patients with advanced carcinoma of esophagus were divided into two groups：18 patients were given Paclitaxel 150 ms／m2 on dayl，and Cisplatin 20 ms／m=from day 2 to day 5 in PTX+DDP group．18 patients were 5-Fu 500 ms／m= dayl一5；and Cisplatin 20 ms／m2 day2—5 in 5Fu+DDP group．Treatment was recycled every 21 days．Results The responserate ofPTX+DDP group much higher than that of 5-Fu+DDP group(66．7％VS 33．3％，P0．05)．The differ- enee was obvious．The adverse effects of the former were mole severse than that of the latter．The major adverse effects were neutropenia and thrombocytopenia．Conclusion The combination of Paclitaxel with Cisplatin is effective in treating advanced oesophageal cancer，but it is essential to manage the adverse effects． Key words：Paclitaxel；Cisplafin；Oesophageal cancer 食管癌是