葛根素治疗挫伤性视网膜病变的疗效观察.doc

医学论文免费下载 葛根素治疗挫伤性视网膜病变的疗效观察 作者：邱莎莎，邓 晓 作者单位：赣南医学院基础医学院，江西 赣州 341000 【摘要】 目的：探讨葛根素治疗挫伤性视网膜病变的临床疗效。方法:选择56例(58眼)挫伤性视网膜病变患者，随机分为治疗组和对照组，治疗组30例患者给予葛根素注射液400 mg，对照组28例患者给予复方丹参注射液20 mL，两组均加入0.9%生理盐水250 mL中静脉点滴，每日1次，15 d为1个疗程，连续2个疗程。观察记录所有患者用药前及用药后第15天、30天的视力、眼底病变情况，并进行荧光眼底造影。比较两组患者病变改变的差异性。结果:①治疗组综合疗效明显优于对照组;②治疗组患者的视力改善显著优于对照组。结论:葛根素治疗挫伤性视网膜病变的疗效显著，是治疗该病的有效的选择药物。 【关键词】 视网膜疾病;挫伤;药物疗法 Effect of puerarin on the therapy of contusive retinopathyQIU Shasha, DENG Xiao(Faculty of Basic Medicine, Gannan Medical College, Ganzhou 341000, China)　[ABSTRACT] Objective: To study the effect of puerarin on the therapy of contusive retinopathy. Methods: Fifty-eights eyes of 56 patients with retinal lesions due to conclusion were divided randomly into trial group (n=30) and control group (n=28). Patients in trial group treated with puerarin 400 mg, once daily for a course of 15 days, continued for 2 courses; patients in control group treated with danshen complex 20 mL, once daily for a course of 15 days, continued for 2 courses; the drugs were diluted using 0.9% NS 400 mL and infused intravenously. The visual acuity and fundus lesions of the patients were observed and recorded before administration, 15 days and 30 days after therapy; fundus fluorescence angiography(FFA) was done. The therapeutic effects were assessed. Results: ①The comprehensive therapeutic effect in trial group was greatly better than that in control group. ②The improvement of vision in trial group was clearly better than that in control group. Conclusion: Puerarin has salient effect on the therapy of contusive retinopathy; its an effective alterative agent for the treatment of contusive retinopathy. [KEY WORDS] Retinopathy; Contusion; Drug therapy 在车祸及其他眼部急性外伤中，挫伤性视网膜病变发生率很高，医生很重视尽快恢复视力。由于患者存在眼部循环和视网膜微循环的双重损害，因此,改善微循环药物在该病的治疗中受到重视。葛根素具有增加血流量，改善微循环，扩张血管，降低血黏度，促纤溶抗血栓等作用。用葛根素注射液治疗挫伤性视网膜病变取得良好疗效,现报告如下。 1 资料与方法 1.1 一般资料 随机选择挫伤性视网膜病变患者56例(58眼)，其中男性33例(34眼)，女性23例(24眼); 年龄10～78岁，平均42岁。病程3～30 d。诊断标准:①有眼外伤或头颅外伤