固相时间分辨荧光免疫分析螯合剂_中间体_4_省略__二溴_6_6_二甲基2_2_.pdf

264 2006 3 16 3 Chinese Journal ofHealth Laboratory Technology, Mar 2006; V ol 16 No 3 固相时间分辨荧光免疫分析螯合剂( ) 中间体) 4, 4c- 二溴- 6, 6c- 二甲基 2, 2c-联吡啶的合成 1 2 3 4 1* 郭淑英 , 潘利华 , 曲晓春, 孔令艳 ,关 铭 ( 11 , 130021; 21 , 130022; 31 , 130024; 41 , 130012) [] : - 4, 4c- - 6, 6c 2, 2c- : , 2- 6-, 6, 6c- - 2, 2c- , 4, 4c- - 6, 6c 2, 2c- : , : 4, 4c- - 6, 6c 2, 2c- : 4, 4c- - 6, 6c 2, 2c- , [] 固相时间分辨荧光免疫分析; 6, 6c- 二甲基- 2, 2c-二吡啶; 4, 4c- 二溴- 6, 6c- 二甲基- 2, 2c- 二吡啶 [] O657 [] [] 1004- 8685( 2006) 03- 0264- 03 Synthesis ofmedia of chelate solid- phase tim e- resolved fluorescence immunoassay) synthesisof4, 4c- dibromo- 6, 6c- dimethyl - 2, 2c- bipyr- idine( ) 1 2 3 4 1* Guo Shu-y ing , P an L i-h ua , Qu X iao-chun , K ong L ing-yan , Guan M ing ( 11Department of Pharmaceutical nalysis, College ofPharmacy, JilinUniversity, Changchun 130021, China; 21Changchun In- stitute of pplied Chem istry, Chinese cademy of Sciences, Changchun 130022, China; 31Northeast NormalUniversity, Chang- chun 130024, China; 41Changchun University ofTechnology, Changchun 130012, China) [Abstract] Objective:To synthesize 4, 4c- dibromo- 6, 6c- dmi ethyl - 2, 2c- bipyridine that is media of chelate solid- phase tmi e- resolved fluorescence mi munoassay1M ethods: 6, 6c- dmi ethyl- 2, 2c- bipyridine was synthesized by diazotization andU llmanncs couple of2- am ino- 6- methylpyridine on the basis of self- d