纤维蛋白原B_多位点基因多态性与其功能表达与脑梗死类型的关系_元小冬.pdf

# 354 # 201026 doi: 10. 3969/ j. issn. 1000-484X.2010.04.015 BB ¹ (华北煤炭医学院附属开滦医院神经内科, 唐山630000) R743 A 1000-484X(2010)04-0354-06 [ ] :(Fibrinogen,Fg) BB-854 / A-455 /A-249C/T-148C/T448 /A Bc-l 1 /A Fg : , 2002 7 - 20036 160 , (MCI)54 ( PCI) 106, 160 , Fg (FMPV) (Amax)( FMPV/Amax) Fg (T ) (VLDL) ,-FgBB :MCI Fg FMPVFMPV/Amax PCI T VLDLFMPV ( P 0. 05) ; FgBB-854A Bc-l 1A , MCI PCI AAA ( P 0. 05) , ( P 0.05) ;MCI FgBB-249T FgFMPV CC ( P 0.05) ;PCI -148T FMPV/Amax CC( P 0.05) ;Bcl-1A Fg ( P 0.05) , PCI FMPV ( P 0.05) :FgBB 5. -249 FMPV ,-148 Fg ;3. Bc-l 1 Fg , MCI ; Fg FMPV/Amax FMPV MCI ,FMPV T PCI [] ; BB ; ; ; The relationship of mult-i lo us gene polymorphisms, fun tional expression of fib- rinogen BB- hain and the type of erebral infar tion YUAN X iao-Dong , WANG Shu-Juan, X U Ya-Ru, LI Jing , YANG N a, LI H ong-Fen. Dep artment o Neurology , Kailuan H osp ital A iliated N orthern China Coal Medical College, Tangshan 063000, China [Abstra t] Obje tive:To study the correlation of B-fibrinogen-854 /A,-455 /A,-249C/T,-148C/T,448 /A and Bcl-1 /A poly- morphisms,functional expression of plasma fibrinogen concentration,molecular reactivity,and the type of cerebral infarction.Methods:A case- control study was used to analyze 54patientswith main-trunk cerebral infarction(MCI) , 106 patients with penetrating-arterial cerebral infarction (PCI) and 160 healthy cases as control group in Kailuan Hospital between July 2002 and June 2003. ene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) . Fg concentration, fibrin monomer polymerized velocity( FM- PV) ,absorbance maximum(Amax) , FMPV/Amax and biochemistry factors including T were meas